Efficiency of mild ovarian stimulation with letrozole co-treatment in expected low ovarian responders.

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JBRA assisted reproduction Pub Date : 2025-10-08 DOI:10.5935/1518-0557.20250161

Alfredo Cortés-Vazquez, Ismael Perez-Bautista, J Andreas Mejicanos-Quiñonez, Hector R Salazar-Ochoa, M Carmen Peraza-Briones, J Daniel Moreno-García, Alfredo L Cortés-Algara

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Abstract

Objective: Ovarian stimulation (OS) is a critical step in assisted reproductive techniques (ART); it has been routinely adopted since it substantially increases the whole process efficiency. Our study aims to compare the efficiency of mild OS with letrozole co-treatment vs. conventional OS in expected low ovarian responders.

Methods: A single-centre, observational, comparative, non-experimental and retrospective study using our database at the Reproductive Endocrinology Department at Centro Médico Nacional 20 de Noviembre in Mexico City was performed.

Results: We compared the total rFSH dosage per oocyte, we noticed a statistically significant difference between groups, Group A 388.9 vs. Group B 667.2IU per retrieved oocyte (p<0.0002, 105 to 450 IU CI 95%), Comparing total rFSH dosage per follicle, we noticed a statistically significant difference among Group A 397.5 vs. Group B 590.2IU per follicle (p<0.014, 39.2 to 346.2 IU, CI 95%).

Conclusions: In expected poor ovarian responders, mild ovarian stimulation with letrozole co-treatment is much more efficient than conventional stimulation.

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轻度卵巢刺激与来曲唑联合治疗预期低卵巢反应的疗效。

目的：卵巢刺激（OS）是辅助生殖技术（ART）的关键步骤；它已被常规采用，因为它大大提高了整个过程的效率。我们的研究旨在比较轻度OS与来曲唑联合治疗与常规OS在预期的低卵巢反应中的效率。方法：单中心、观察性、比较性、非实验性和回顾性研究使用我们在墨西哥城国立11月20日生殖内分泌科的数据库进行。结果：我们比较了每个卵母细胞的rFSH总剂量，我们注意到组间差异有统计学意义，a组388.9 vs B组667.2IU /卵母细胞。结论：在预期的卵巢不良反应中，轻度卵巢刺激与来曲唑联合治疗比常规刺激有效得多。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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JBRA assisted reproduction

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