Anisotropic wear behavior of meniscus: Influence of cross-shear and loading magnitude

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-09-23 DOI:10.1016/j.jmbbm.2025.107212

Kate J. Benfield , Katherine J. Fors , Trevor C. Black , Giada A. Brandes , Karlee M. Macaw , Vanessa Bowman , Cynthia Keller-Peck , Trevor J. Lujan

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Abstract

The repetitive wear-and-tear of knee menisci contributes to chronic knee pain and disability, yet the mechanical factors driving this degenerative process are poorly understood. Here we characterize the effect of motion type and loading magnitude on the anisotropic wear behavior of bovine meniscus. Custom pin-on-plate systems applied 60,000 cycles of unidirectional motion or multidirectional (cross-shear) motion by translating a sectioned “plate” of meniscus under a fixed cartilage “pin” that was loaded to generate physiological stress conditions (0.5, 1.0, 1.5 MPa). Pin motion was applied either longitudinal or transverse to the circumferential fibers of the meniscal tissue. We measured the effect of wear testing on meniscal volume loss, compressive mechanical properties, fiber fraying, and superficial layer thickness. A three-fold increase in loading magnitude resulted in a 36% increase in volume loss and a significant increase in fiber fraying. Multidirectional motion resulted in 31% greater volume loss than unidirectional motion, however, this change was not significant. Transverse specimens exhibited 1.8x greater volume loss than longitudinal specimens. Multiple regression revealed that meniscal tissue was more resistant to wear when it had higher initial tissue stiffness and greater initial stress relaxation. For the first time, this study has demonstrated that the meniscus exhibits anisotropic wear behavior that is governed by the compressive loading magnitude. This study provides foundational data and mechanistic insights on the wear behavior of the knee meniscus.

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半月板各向异性磨损行为：交叉剪切和载荷大小的影响。

膝关节半月板的反复磨损会导致慢性膝关节疼痛和残疾，但驱动这种退行性过程的机械因素尚不清楚。本文研究了运动类型和载荷大小对牛半月板各向异性磨损行为的影响。定制的板上钉系统通过在固定软骨“钉”下平移半月板切片“板”来产生生理应力条件（0.5,1.0,1.5 MPa），从而实现60,000次单向运动或多向（交叉剪切）运动。在半月板组织的周向纤维上施加纵向或横向的针运动。我们测量了磨损测试对半月板体积损失、压缩力学性能、纤维磨损和表层厚度的影响。载荷增加3倍，导致体积损失增加36%，纤维磨损显著增加。多向运动导致的体积损失比单向运动多31%，但这种变化并不显著。横向试件的体积损失是纵向试件的1.8倍。多元回归分析表明，初始组织刚度越大，初始应力松弛越大，半月板组织耐磨性越强。这项研究首次证明了半月板表现出各向异性磨损行为，这是由压缩载荷大小决定的。本研究提供了关于膝关节半月板磨损行为的基础数据和机理见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.