Association of standard dietary inflammatory index with diabetic retinopathy in diabetes: A prospective cohort study

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-10-07 DOI:10.1016/j.jnha.2025.100694

Zihan Xu , Feipeng Jiang , Yun Zhang , Jier Ma , Jianjun Ren , Meixia Zhang

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引用次数: 0

Abstract

Background and aims

Diabetic retinopathy (DR) is a major cause of vision impairment, and its development is linked to chronic inflammation. Investigating the role of dietary patterns, specifically the standard dietary inflammatory index (DII), may provide insights into modifiable risk factors for DR.

Objective

To quantify the impact of dietary inflammatory potential (assessed via the standard DII) on both risk of DR and structural alterations across individual retinal layers.

Methods

We conducted a prospective cohort study using data from the UK Biobank. Cox proportional hazards models and restricted cubic splines were used to examine the correlation between the standard DII and DR in three adjusted models. Sensitivity analyses were performed to test the robustness of the outcomes. Linear regression models were employed to explore the associations between the standard DII and retinal structural parameters.

Results

Data from 16,224 participants with diabetes from the UK Biobank were analyzed, including 1,257 (7.75%) who developed DR during the follow-up period. Higher standard DII scores were associated with an increased risk of DR in all adjusted models [Model 3: HR = 1.51, 95% CI: (1.15, 1.99), p = 0.003]. A J-shaped association between standard DII scores and DR was observed, and the relationship was significant only when the standard DII score was greater than −2.5 [HR = 1.59, 95% CI: (1.44, 2.04), p = 0.002]. Subgroup analyses revealed consistent results across different stratified groups, indicating increased DR risk. Image analysis revealed that standard DII scores were associated with the thinning of the retinal pigment epithelium layer.

Conclusions

Our findings suggest a J-shaped association between standard DII score and DR risk in a multiracial sample from the UK Biobank. These findings indicate that an anti-inflammatory diet may be promising for mitigating the onset of DR.

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标准饮食炎症指数与糖尿病视网膜病变的相关性：一项前瞻性队列研究。

背景和目的：糖尿病性视网膜病变（DR）是视力损害的主要原因，其发展与慢性炎症有关。研究饮食模式的作用，特别是标准饮食炎症指数（DII），可能为DR的可改变危险因素提供见解。目的：量化饮食炎症潜力（通过标准DII评估）对DR风险和个体视网膜层结构改变的影响。方法：我们使用来自英国生物银行的数据进行了一项前瞻性队列研究。采用Cox比例风险模型和受限三次样条检验三种调整模型中标准DII与DR之间的相关性。进行敏感性分析以检验结果的稳健性。采用线性回归模型探讨标准DII与视网膜结构参数之间的关系。研究人员分析了来自英国生物银行（UK Biobank）的16224名糖尿病患者的数据，其中1257名（7.75%）在随访期间发生了DR。在所有调整后的模型中，较高的标准DII评分与DR风险增加相关[模型3:HR = 1.51, 95% CI:(1.15, 1.99), p = 0.003]。标准DII评分与DR呈j型相关，且只有当标准DII评分大于-2.5时，这种关系才具有显著性[HR = 1.59, 95% CI: (1.44, 2.04), p = 0.002]。亚组分析显示，不同分层组的结果一致，表明DR风险增加。图像分析显示，标准DII评分与视网膜色素上皮层变薄有关。结论：我们的研究结果表明，在英国生物银行的多种族样本中，标准DII评分与DR风险之间存在j型关联。这些发现表明，抗炎饮食可能有希望减轻DR的发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.