New insights into signaling networks coordinating epidermal stem cell regulation in skin regeneration and aging

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-10-07 DOI:10.1016/j.ceb.2025.102594

Mizuho Ishikawa , Hung Manh Phung , Thisakorn Dumrongphuttidecha , Aiko Sada

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引用次数: 0

Abstract

The skin is a dynamic, regenerative organ capable of withstanding diverse internal and external stresses, supported by tissue-resident stem cells. A complex signaling network regulates interactions between epidermal stem cells, dermal cells, immune cells, and the extracellular matrix to maintain tissue integrity. Disruptions in these signaling pathways can impair cellular communication, alter stem cell lineage commitment, and compromise epidermal stem cell identity, ultimately resulting in a loss of coordinated tissue function. In this review, we highlight recent insights into three key signaling factors—metabolic, mechanical, and inflammatory cues—that regulate epidermal stem cell behavior during homeostasis, regeneration, and aging. We further discuss how dysregulation of these pathways contributes to pathological skin remodeling and explore emerging intervention strategies targeting signaling molecules to restore epidermal stem cell function and skin health.

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在皮肤再生和衰老中协调表皮干细胞调节的信号网络的新见解。

皮肤是一个动态的再生器官，能够承受各种内部和外部压力，由组织驻留干细胞支持。一个复杂的信号网络调节表皮干细胞、真皮细胞、免疫细胞和细胞外基质之间的相互作用，以维持组织的完整性。这些信号通路的中断会损害细胞通讯，改变干细胞谱系的承诺，损害表皮干细胞的身份，最终导致协调组织功能的丧失。在这篇综述中，我们重点介绍了最近对调节表皮干细胞在稳态、再生和衰老过程中的行为的三个关键信号因子——代谢、机械和炎症信号的见解。我们进一步讨论了这些通路的失调如何促进病理性皮肤重塑，并探索了针对信号分子的新兴干预策略，以恢复表皮干细胞功能和皮肤健康。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.