Impact of creatine supplementation and exercise training in older adults: a systematic review and meta-analysis.

IF 3.5 1区医学 Q2 GERIATRICS & GERONTOLOGY

European Review of Aging and Physical Activity Pub Date : 2025-10-08 DOI:10.1186/s11556-025-00384-9

Ghazal Sharifian, Parastou Aseminia, Diako Heidary, Joseph I Esformes

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Abstract

The aim of this study is to assess the effects of the combination of and exercise training on older adults' physical performance and body composition. This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Scopus, Web of Science, and PubMed databases (date of access: 30 August 2024) were queried. Twenty articles met the inclusion criteria and a total of 1093 participants (69% females and 31% males) were included in the study. The mean difference (MD) with 95% confidence intervals (CIs) and the overall effect size was calculated for all comparisons between the creatine plus exercise training group and placebo plus exercise training group. The PEDro scale was used to evaluate the quality of articles. Our findings showed that creatine intake and exercise training significantly affect 1RM (kg) in older adults (mean difference = 2.122, Z = 3.255, P = 0.001). There was a significant effect on fat percentage (%) in older adults (mean difference = -0.548, Z = -2.231, P = 0.026), while creatine intake and exercise training did not have a significant effect on bone mineral density (BMD) of total body (g/cm²) in older adults (mean difference = 0.009, Z = 0.587, P = 0.557). By participating in exercise training programs and creatine supplementation, older adults can improve their functional performance and body composition. However, the effects of exercise training and creatine supplementation on BMD require further study (PROSPERO registration number: CRD42024581817).

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肌酸补充和运动训练对老年人的影响：一项系统回顾和荟萃分析。

本研究的目的是评估结合训练和运动训练对老年人身体机能和身体成分的影响。本荟萃分析是根据系统评价和荟萃分析首选报告项目（PRISMA）指南进行的。查询Scopus、Web of Science和PubMed数据库（存取日期：2024年8月30日）。20篇文章符合纳入标准，共纳入1093名参与者（69%为女性，31%为男性）。计算肌酸加运动训练组和安慰剂加运动训练组之间所有比较的95%置信区间（ci）的平均差（MD）和总体效应大小。采用PEDro量表评价文章质量。我们的研究结果显示，肌酸摄入和运动训练显著影响老年人的1RM (kg)（平均差异= 2.122,Z = 3.255, P = 0.001）。肌酸摄入和运动训练对老年人的脂肪百分比（%）有显著影响（平均差异= -0.548,Z = -2.231, P = 0.026），而对老年人全身骨密度（g/cm2）无显著影响（平均差异= 0.009,Z = 0.587, P = 0.557）。通过参加运动训练计划和补充肌酸，老年人可以改善他们的功能表现和身体成分。然而，运动训练和补充肌酸对BMD的影响需要进一步研究（PROSPERO注册号：CRD42024581817）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Review of Aging and Physical Activity 医学-老年医学

CiteScore

8.60

自引率

1.60%

发文量

审稿时长

>12 weeks

期刊介绍： European Review of Aging and Physical Activity (EURAPA) disseminates research on the biomedical and behavioural aspects of physical activity and aging. The main issues addressed by EURAPA are the impact of physical activity or exercise on cognitive, physical, and psycho-social functioning of older people, physical activity patterns in advanced age, and the relationship between physical activity and health.