Characterization of Self-Administered Olfactory Assessments Novel Olfactory Sorting Task (NOST) and Odor Dilution Sorting (ODS) in a Community-Based Population.

IF 2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laryngoscope Pub Date : 2025-10-08 DOI:10.1002/lary.70190

Tiana M Saak, Renjie Zhang, Matthew D A Spence, Davangere P Devanand, Jeffrey N Motter, Jonathan B Overdevest

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引用次数: 0

Abstract

Objectives: Olfactory evaluation beyond conventional domain testing may inform how olfactory impairment presents among the general population. Recently reported assessments based on odor matching (NOST) and intensity sorting (ODS) may provide additional insight into olfactory function. Characterizing performance of these simple and self-administered tasks among a community-based population offers a valuable benchmark for subsequent evaluation in aging and cognition-impaired cohorts.

Methods: Seventy community-based individuals completed Sniffin' Sticks TDI testing, NOST, and ODS. NOST is an odor matching task among twelve pairs of odorants, and ODS is an odor intensity scaling task. Scores were compared to TDI using Spearman correlations and Wilcoxon signed-rank tests.

Results: NOST median score was 6 (IQR: 4, 9) while ODS was 0.80 (0.70, 0.85). NOST correlated with TDI (r; [confidence interval]: 0.640, [0.47, 0.76]), threshold (0.342; [0.11, 0.54]), discrimination (0.556; [0.36, 0.70]), and identification (0.297, [0.06, 0.50]), but not with ODS. Participants performed significantly better on the ODS-Eugenol trial than on the ODS-PEA trial, with median scores of 0.90 (IQR: 0.80, 1.0) and 0.70 (0.50, 0.80), respectively (p < 0.001).

Conclusions: NOST correlates strongly with odor discrimination in this community-based population, while ODS shows no significant correlations with any TDI subdomains. The lack of several strong correlations on either assessment with overall TDI suggests these assessments may evaluate domains of smell and cognition not previously captured by standalone TDI testing. Continued validation of NOST and ODS across a broad population with ranging olfactory and cognitive statuses is needed to fully characterize the utility of these well-tolerated, self-administered olfactory tests.

Level of evidence: 2:

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基于社区人群自我嗅觉评估的特征：新型嗅觉分类任务（NOST）和气味稀释分类（ODS）。

目的：嗅觉评估超越传统的领域测试可能会告诉嗅觉障碍是如何在普通人群中出现的。最近报道的基于气味匹配（NOST）和强度排序（ODS）的评估可能为嗅觉功能提供额外的见解。在以社区为基础的人群中描述这些简单和自我管理的任务的表现，为老年和认知障碍人群的后续评估提供了有价值的基准。方法：70名社区个体完成嗅探棒TDI、NOST和ODS测试。NOST是12对气味剂之间的气味匹配任务，ODS是气味强度尺度任务。使用Spearman相关和Wilcoxon符号秩检验将得分与TDI进行比较。结果：NOST中位评分为6 (IQR: 4,9)， ODS为0.80（0.70,0.85）。NOST与TDI （r；[置信区间]:0.640,[0.47,0.76]）、阈值（0.342,[0.11,0.54]）、辨别力（0.556,[0.36,0.70]）、识别力（0.297,[0.06,0.50]）相关，与ODS无关。参与者在ODS-丁香酚试验中的表现明显优于ODS- pea试验，中位得分分别为0.90 （IQR: 0.80, 1.0）和0.70 (0.50,0.80)(p)。结论：NOST与社区人群的气味辨别有很强的相关性，而ODS与任何TDI子域没有显著相关性。两种评估与整体TDI之间缺乏几个强相关性，这表明这些评估可能评估嗅觉和认知领域，而不是以前单独的TDI测试所捕获的。需要在具有不同嗅觉和认知状态的广泛人群中继续验证NOST和ODS，以充分表征这些耐受性良好、自我管理的嗅觉测试的效用。证据等级:2;

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来源期刊

Laryngoscope 医学-耳鼻喉科学

CiteScore

6.50

自引率

7.70%

发文量

500

审稿时长

2-4 weeks

期刊介绍： The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope. • Broncho-esophagology • Communicative disorders • Head and neck surgery • Plastic and reconstructive facial surgery • Oncology • Speech and hearing defects