Slight acceleration in podocyte mRNA loss in preterm-born children aged 3-5 years.

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-10-08 DOI:10.1007/s00467-025-06983-z

Zhengqi Cui, Chao Ning, Junling Ma, Lulu Zhang, Xueou Liu, Li Kong, Ying Chang, Fangrui Ding

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引用次数: 0

Abstract

Background: The global survival rate of preterm infants has been progressively increasing. However, concerns regarding their long-term prognosis persist. This study aimed to investigate podocyte mRNA loss in 3-5-year-old full-term and preterm children to elucidate the role of podocyte depletion in the pathogenesis of chronic kidney disease (CKD) in preterm infants.

Methods: A total of 80 children aged 3-5 years, born at Tianjin Central Hospital of Gynecology and Obstetrics, were included in this study: 42 preterm infants (gestational age 24-29 weeks) and 38 full-term infants. Morning urine samples were collected to examine podocyte mRNA levels (expressed as the urinary podocin mRNA-to-creatinine ratio, UpodCR), urine protein, and urine albumin levels. The impact of perinatal factors on UpodCR was also analyzed.

Results: Results indicated that the rate of podocyte mRNA loss in the preterm group was significantly higher than in the full-term group (1.54-fold). No significant differences were observed in urine protein and urine albumin levels between the two groups. Perinatal factor analysis revealed that gestational age and antenatal corticosteroid use were significant risk factors for podocyte loss in childhood.

Conclusions: This study is the first to confirm accelerated podocyte loss in the urine of 3-5-year-old preterm children. Although less severe than in the early postnatal period, it remains higher than in full-term children, providing crucial evidence for the involvement of podocyte depletion in the pathogenesis of preterm-related CKD. It also underscores the need for careful evaluation of the benefits and risks associated with antenatal corticosteroid use.

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3-5岁早产儿足细胞mRNA丢失轻微加速。

背景：全球早产儿的存活率正在逐步提高。然而，对其长期预后的担忧仍然存在。本研究旨在研究3-5岁足月和早产儿足细胞mRNA丢失，以阐明足细胞缺失在早产儿慢性肾脏疾病（CKD）发病机制中的作用。方法：选取天津市中心妇产医院出生的3 ~ 5岁儿童80例为研究对象，其中早产儿42例（胎龄24 ~ 29周），足月儿38例。收集晨尿样本，检测足细胞mRNA水平（表达为尿足蛋白mRNA与肌酐比值，updcr）、尿蛋白和尿白蛋白水平。分析围产期因素对updrr的影响。结果：早产组足细胞mRNA丢失率明显高于足月组（1.54倍）。尿蛋白和尿白蛋白水平在两组间无显著差异。围产期因素分析显示，胎龄和产前皮质类固醇使用是儿童足细胞丢失的重要危险因素。结论：这项研究首次证实了3-5岁早产儿尿液中足细胞的加速丢失。虽然没有出生早期严重，但仍高于足月儿童，这为早产儿相关CKD发病机制中足细胞耗竭的参与提供了重要证据。它还强调需要仔细评估与产前使用皮质类固醇相关的益处和风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.