Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-10-09 DOI:10.1007/s10072-025-08554-4

Xinpeng Wang, Xiaoyu Li, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han

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引用次数: 0

Abstract

Objective: To describe causes, clinical manifestations, imaging features and prognosis of reversible splenial lesion syndrome (RESLES) in children.

Methods: A total of 36 patients with RESLES hospitalized in Children's Hospital of Chongqing Medical University between January 1, 2017 and Mar 31, 2024 were included. The clinical features including the causes, clinical manifestations and prognosis were statistically analyzed.

Results: The patients' ages ranged from 16 to 170 months with a median age of 49 months. Of the 36 patients, 24 patients were RESLES type-1 (the lesions were limited to SCC) and 12 patients were RESLES type-2(the lesions spread to other parts of the corpus callosum, extensive brain white matter, or both). The participating causes included infection, chemotherapy, immunoglobulin A vasculitis, autoimmune glial fibrillary acidic protein astrocytopathy, hypertension and hypoparathyroidism. The common neurological symptoms were seizures(n = 27), headache(n = 10), dizziness(n = 6), altered consciousness(n = 8), and psychologico-behavioral abnormalities(n = 14). Most patients had a good prognosis except 1 patient remained in a state of minimal consciousness during the follow-up.

Conclusion: This research demonstrates some possible causes of RESLES. Patients with RESLES present with a variety of nonspecific symptoms and most of them had a good prognosis.

Significance: These findings are groundbreaking to a deeper understanding of RESLES.

查看原文本刊更多论文

儿童可逆性脾损害综合征的新病因及临床特点。

目的：探讨儿童可逆性脾损害综合征（RESLES）的病因、临床表现、影像学特征及预后。方法：选取重庆医科大学附属儿童医院2017年1月1日至2024年3月31日收治的RESLES患儿36例。统计分析其临床特点，包括病因、临床表现及预后。结果：患者年龄16 ~ 170个月，中位年龄49个月。在36例患者中，24例为RESLES 1型（病变仅限于SCC）， 12例为RESLES 2型（病变扩散到胼胝体的其他部位，广泛的脑白质，或两者兼而有之）。参与的原因包括感染、化疗、免疫球蛋白A血管炎、自身免疫性胶质纤维酸性蛋白星形细胞病、高血压和甲状旁腺功能低下。常见的神经系统症状为癫痫发作（27例）、头痛（10例）、头晕（6例）、意识改变（8例）和心理行为异常（14例）。除1例患者在随访期间仍处于最低意识状态外，大多数患者预后良好。结论：本研究揭示了RESLES的一些可能原因。RESLES患者表现出多种非特异性症状，多数预后良好。意义：这些发现对于深入了解RESLES具有开创性意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.