Feng Tang, Jia-Long Xu, Qing Zhang, Xi Chen, Ze-Fen Wang, Ya-Di Xu, Zhi-Qiang Li
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引用次数: 0
Abstract
Immune checkpoints (ICs) maintain immune homeostasis by suppressing excessive T-cell activation. Their dysregulated expression or signaling facilitates tumor immune evasion, thereby undermining the effectiveness of cancer immunotherapies. Palmitoylation, a reversible post-translational modification, covalently attaches palmitate to cysteine residues, altering protein localization, stability, and function. Recent studies have indicated that palmitoylation of the IC-related signaling pathway governs their membrane trafficking, signaling activity, and interactions with effector molecules, ultimately shaping anti-tumor immune responses. This review integrates the current understanding of palmitoylation mechanisms, examines their role in IC regulation, explores potential immunotherapeutic applications, and highlights future research directions.
期刊介绍：
Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.
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