THE STATIC ELECTROCARDIOGRAM OF ZOO-KEPT NAKED MOLE-RATS (HETEROCEPHALUS GLABER) UNDER ALFAXALONE-KETAMINE ANESTHESIA.

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Zoo and Wildlife Medicine Pub Date : 2025-10-01 DOI:10.1638/2024-0116

Nathan Boyd, Justin Thomason, Neta Ambar, Trenton Shrader, David Eshar

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Abstract

The naked mole-rat (Heterocephalus glaber) has become a subject of interest in cardiovascular research due to its unique biological properties. However, the ECG of this species has not been thoroughly described. The objective of this study was to characterize the ECG of ten clinically healthy naked mole-rats. Each animal was anesthetized with ketamine and alfaxalone, and ECGs were recorded in sternal recumbency using a hexaxial lead system. ECG resembled those of other rodents with a median heart rate of 174 beats/min (range: 131-202 beats/min), positive Q wave, R wave, and S wave (QRS) complexes in lead II, and absence of an isoelectric ST segment. All P waves were low amplitude (range: 0-0.05 millivolts (mV)) and <40 milliseconds (ms) in duration (26-33 ms) while the median PR interval was 85 ms (76-100 ms). Peak R wave amplitudes ranged from 0.26-1.15 mV depending on filter settings and QRS complex durations were 26-44 ms. The QT intervals ranged from 168-254 ms. An arrhythmia characterized by sinus rhythm with first- and second-degree atrioventricular block was noted in one animal. Collectively, these results provide baseline values in clinically healthy naked mole-rats, which will be relevant to clinical and research situations.

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阿法沙酮-氯胺酮麻醉下动物园裸鼹鼠静态心电图的观察。

裸鼹鼠（Heterocephalus glaber）因其独特的生物学特性而成为心血管研究的热点。然而，该物种的心电图尚未被彻底描述。本研究的目的是描述10只临床健康裸鼹鼠的心电图特征。用氯胺酮和阿法索酮麻醉各组动物，采用六轴导联系统记录胸骨平卧位心电图。心电图与其他啮齿动物相似，中位心率为174次/分（范围：131-202次/分），II导联Q波、R波和S波（QRS）正复合物，ST段等电性缺失。所有P波均为低幅值（范围：0-0.05毫伏），P波均为低幅值

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来源期刊

Journal of Zoo and Wildlife Medicine 农林科学-兽医学

CiteScore

1.70

自引率

14.30%

发文量

审稿时长

9-24 weeks

期刊介绍： The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.