Global, regional, and national burden of lower extremity peripheral arterial disease: a systematic analysis of prevalence, incidence, deaths, and dalys from 1990 to 2021 with projections and dietary risk factors to 2036.

IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES
Yujun He, Miao Zhou, Jie Tang, Yaling Zheng, Jianying Chen, Bowen Xing, Dan Li, Mengya Liang, Weiwei Tang, Xiaojun Li, Xiaoyi Wang
{"title":"Global, regional, and national burden of lower extremity peripheral arterial disease: a systematic analysis of prevalence, incidence, deaths, and dalys from 1990 to 2021 with projections and dietary risk factors to 2036.","authors":"Yujun He, Miao Zhou, Jie Tang, Yaling Zheng, Jianying Chen, Bowen Xing, Dan Li, Mengya Liang, Weiwei Tang, Xiaojun Li, Xiaoyi Wang","doi":"10.1186/s41043-025-01094-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This research aims to analyze the global, regional, and national burden of LE-PAD from 1990 to 2021 through the GBD 2021 database. We also assess the impact of dietary risk factors and use decomposition and frontier analyses to identify key drivers and disparities in disease burden.</p><p><strong>Methods: </strong>We used data from the GBD 2021 study (covering 204 countries and territories) to analyze LE-PAD-related prevalence, incidence, mortality, and DALYs, and conducted trend analysis and projections via joinpoint regression and autoregressive integrated moving average (ARIMA) models. Decomposition analysis evaluated the contributions of population growth, aging, and epidemiological changes, and frontier analysis identified countries with high LE-PAD rates relative to their SDI.</p><p><strong>Results: </strong>From 1990 to 2021, global LE-PAD prevalence and incidence rose significantly. Females had higher prevalence, and males under 75 had higher mortality. Dietary risk factors like high processed meat and low whole-grain intake were major contributors. Population growth drove the increased burden, somewhat mitigated by epidemiological changes. Frontier analysis showed country disparities, with some high-income countries having relatively high LE-PAD burden.</p><p><strong>Conclusion: </strong>The growing burden of LE-PAD demands targeted interventions, better healthcare infrastructure, and sustained research. Addressing modifiable risk factors, promoting healthy lifestyles, and conducting effective public health campaigns and education are crucial to reduce its impact.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":"44 1","pages":"351"},"PeriodicalIF":2.8000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health, Population, and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s41043-025-01094-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: This research aims to analyze the global, regional, and national burden of LE-PAD from 1990 to 2021 through the GBD 2021 database. We also assess the impact of dietary risk factors and use decomposition and frontier analyses to identify key drivers and disparities in disease burden.

Methods: We used data from the GBD 2021 study (covering 204 countries and territories) to analyze LE-PAD-related prevalence, incidence, mortality, and DALYs, and conducted trend analysis and projections via joinpoint regression and autoregressive integrated moving average (ARIMA) models. Decomposition analysis evaluated the contributions of population growth, aging, and epidemiological changes, and frontier analysis identified countries with high LE-PAD rates relative to their SDI.

Results: From 1990 to 2021, global LE-PAD prevalence and incidence rose significantly. Females had higher prevalence, and males under 75 had higher mortality. Dietary risk factors like high processed meat and low whole-grain intake were major contributors. Population growth drove the increased burden, somewhat mitigated by epidemiological changes. Frontier analysis showed country disparities, with some high-income countries having relatively high LE-PAD burden.

Conclusion: The growing burden of LE-PAD demands targeted interventions, better healthcare infrastructure, and sustained research. Addressing modifiable risk factors, promoting healthy lifestyles, and conducting effective public health campaigns and education are crucial to reduce its impact.

下肢外周动脉疾病的全球、区域和国家负担:1990年至2021年的患病率、发病率、死亡和天数的系统分析,并预测到2036年的饮食风险因素。
目的:本研究旨在通过GBD 2021数据库分析1990 - 2021年全球、地区和国家的LE-PAD负担。我们还评估了饮食风险因素的影响,并使用分解和前沿分析来确定疾病负担的关键驱动因素和差异。方法:我们使用GBD 2021研究(覆盖204个国家和地区)的数据分析le - pad相关的患病率、发病率、死亡率和DALYs,并通过联合点回归和自回归综合移动平均(ARIMA)模型进行趋势分析和预测。分解分析评估了人口增长、老龄化和流行病学变化的贡献,前沿分析确定了相对于其SDI而言LE-PAD发生率较高的国家。结果:1990 - 2021年,全球LE-PAD患病率和发病率显著上升。女性患病率较高,75岁以下男性死亡率较高。高加工肉类和低全谷物摄入量等饮食风险因素是主要因素。人口增长导致负担增加,但流行病学变化在一定程度上减轻了负担。前沿分析显示了国家差异,一些高收入国家的LE-PAD负担相对较高。结论:LE-PAD负担不断增加,需要有针对性的干预措施、更好的医疗基础设施和持续的研究。处理可改变的风险因素,促进健康的生活方式,开展有效的公共卫生运动和教育,对于减少其影响至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Health, Population, and Nutrition
Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.20
自引率
0.00%
发文量
49
审稿时长
6 months
期刊介绍: Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信