Correlating head kinematics and cervical cerebrospinal fluid pressure transients in simulated whiplash exposures.

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics Pub Date : 2025-10-01 DOI:10.1016/j.jbiomech.2025.112994

Nikoo Soltan, Mats Y Svensson, Claire F Jones, Peter A Cripton, Gunter P Siegmund

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引用次数: 0

Abstract

The origin and mechanics of whiplash injury from motor vehicle collisions are poorly understood. Among the proposed injury mechanisms, the inertial loading of the head and neck during whiplash exposures is theorized to produce injurious cerebrospinal fluid pressure (CSFP) transients. To better understand the mechanics and modal behavior of CSFP transients during whiplash exposures, we quantified the time-frequency relationship between input head kinematics and cervical CSFP responses in an in vivo pig model. Wavelet coherence analysis was used to correlate seven head kinematic parameters (including temporal Neck Injury Criterion, NIC) with CSFP during simulated extension and flexion whiplash exposures. Overall, the first and last 50 ms of exposures, and frequency ranges between 30-65 Hz had larger coherences between head kinematics and CSFP, with higher coherences in extension exposures than flexion exposures. NIC did not universally outperform other head kinematic parameters as a correlate of CSFP. These findings highlight the complexity of the dynamics involved in generating CSFP transients in the cervical spine during whiplash exposures.

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模拟鞭打暴露中头部运动学和颈脑脊液压力瞬变的相关性

机动车碰撞引起的颈部扭伤的起源和机理尚不清楚。在提出的损伤机制中，头颈部暴露时的惯性负荷理论上会产生损伤性脑脊液压力（CSFP）瞬变。为了更好地理解鞭打暴露过程中CSFP瞬态的力学和模态行为，我们在猪体内模型中量化了输入头部运动学和颈椎CSFP响应之间的时频关系。小波相干性分析将七个头部运动学参数（包括颞颈损伤标准，NIC）与模拟伸展和屈曲扭伤暴露时的cspp相关联。总的来说，暴露的前50毫秒和最后50毫秒，频率范围在30-65 Hz之间，头部运动学和ccsf之间具有较大的相干性，伸展暴露的相干性高于屈曲暴露。NIC并没有普遍优于其他头部运动学参数作为CSFP的相关。这些发现强调了颈椎在鞭打暴露过程中产生cfp瞬态的动力学复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomechanics 生物-工程：生物医学

CiteScore

5.10

自引率

4.20%

发文量

345

审稿时长

1 months

期刊介绍： The Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical, as well as experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership. Papers published in the journal may cover a wide range of topics in biomechanics, including, but not limited to: -Fundamental Topics - Biomechanics of the musculoskeletal, cardiovascular, and respiratory systems, mechanics of hard and soft tissues, biofluid mechanics, mechanics of prostheses and implant-tissue interfaces, mechanics of cells. -Cardiovascular and Respiratory Biomechanics - Mechanics of blood-flow, air-flow, mechanics of the soft tissues, flow-tissue or flow-prosthesis interactions. -Cell Biomechanics - Biomechanic analyses of cells, membranes and sub-cellular structures; the relationship of the mechanical environment to cell and tissue response. -Dental Biomechanics - Design and analysis of dental tissues and prostheses, mechanics of chewing. -Functional Tissue Engineering - The role of biomechanical factors in engineered tissue replacements and regenerative medicine. -Injury Biomechanics - Mechanics of impact and trauma, dynamics of man-machine interaction. -Molecular Biomechanics - Mechanical analyses of biomolecules. -Orthopedic Biomechanics - Mechanics of fracture and fracture fixation, mechanics of implants and implant fixation, mechanics of bones and joints, wear of natural and artificial joints. -Rehabilitation Biomechanics - Analyses of gait, mechanics of prosthetics and orthotics. -Sports Biomechanics - Mechanical analyses of sports performance.