Cytomegalovirus Secretion in Breast Milk of Mothers Delivering at ≤ 32 Weeks' Gestation: A Prospective Observational Study.

IF 1.5 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-10-08 DOI:10.1007/s13312-025-00203-5

Zubair Ahmad Bhat, Mohamed Muneer Varikkottil, Femitha Pournami, Ajai Kumar Prithvi, Naveen Jain

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Abstract

Objectives: Preterm neonates are at risk of symptomatic postnatal cytomegalovirus (pCMV) acquired from CMV-positive breast milk intake. This study ascertained the proportion of mothers delivering at ≤ 32 weeks' gestation with CMV lactatia.

Methods: This prospective study included mother-infant dyads delivered at ≤ 32 weeks' gestation. CMV was detected in breast milk by quantitative DNA PCR. For the proportion of neonates who tested positive for CMV DNA (urine or blood) at 4-6 weeks of age, clinical outcomes were also measured. CMV load > 42.5 copies/mL was considered positive. Virologic (breast milk and infant blood/urine CMV PCR) and clinical correlates were evaluated.

Results: Out of the 93 mothers whose fresh breast milk was tested, 50 (53.7%, 95%CI 42.3, 55.9%) were positive for CMV. Out of 43 infants who were tested for CMV in blood or urine at 4-6 weeks of postnatal age, 10 (23%, 95%CI 18.1, 28.6%) turned positive. Significant differences were noted in the duration of respiratory support [47.5 (30, 73) vs 7 (3, 30) days; P = 0.002] and hospital stay [86.5 (80, 98) vs 51 (31, 65) days, P < 0.001] between CMV positive and negative infants. CMV-positive status was not an independent risk factor for bronchopulmonary dysplasia [aOR 5.3 (95%CI 0.9-31.0)] and retinopathy of prematurity requiring therapy [aOR 17.3 (95%CI 0.9-194.2)].

Conclusion: 53.7% of mothers delivering prematurely had CMV lactatia; 23% of their infants were positive for CMV at 4-6 weeks of age.

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妊娠≤32周产妇乳汁巨细胞病毒分泌：一项前瞻性观察研究

目的：摄入巨细胞病毒（cmv）阳性的母乳后，早产儿有感染症状性巨细胞病毒（pCMV）的风险。本研究确定了在妊娠≤32周分娩时携带巨细胞病毒乳汁的母亲的比例。方法：本前瞻性研究纳入了妊娠≤32周分娩的母婴。采用定量DNA PCR检测母乳中巨细胞病毒。对于在4-6周龄时CMV DNA（尿液或血液）检测呈阳性的新生儿比例，也测量了临床结果。CMV载量> 42.5拷贝/mL为阳性。病毒学（母乳和婴儿血液/尿液巨细胞病毒PCR）和临床相关性进行了评估。结果：在93例新鲜母乳检测中，50例（53.7%,95%CI 42.3, 55.9%） CMV阳性。在出生后4-6周接受血液或尿液巨细胞病毒检测的43名婴儿中，有10名（23%,95%CI 18.1, 28.6%）呈阳性。呼吸支持持续时间有显著差异[47.5（30,73）天和7（3,30）天；P = 0.002]和住院天数[86.5（80,98）对51（31,65）天]，P结论：53.7%的早产母亲有乳母巨细胞病毒；23%的婴儿在4-6周龄时呈巨细胞病毒阳性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.