Plasma ALKAL2 levels are associated with coronary atherosclerosis in patients with type 2 diabetes mellitus.

IF 10.6 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Diabetology Pub Date : 2025-10-08 DOI:10.1186/s12933-025-02948-6

Yipaerguli Maimaiti, Minhui Wang, Shuai Chen, Feifei Li, Jingmeng Liu, Xinrui Wu, Jianjun Chen, Qiujing Chen, Weifeng Shen, Fenghua Ding, Yang Dai, Lin Lu

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Abstract

Background: Cancer-associated signaling pathways, particularly the ALK/LTK receptor tyrosine kinases and their ligand ALKAL2, have recently been implicated in chronic inflammation and myocardial remodeling. However, the relationship between ALKAL2 and coronary artery disease (CAD) pathogenesis in type 2 diabetes mellitus (T2DM) remains undefined.

Methods: From January 2019 to December 2020, patients with type 2 diabetes mellitus (T2DM) undergoing coronary angiography were consecutively enrolled at Ruijin Hospital. Plasma ALKAL2 levels were measured using an ELISA assay. The association between ALKAL2 and CAD severity was assessed by Spearman correlation analysis. Logistic regression models were used to measure the association between ALKAL2 and CAD risk.

Results: 275 T2DM patients with CAD and 275 age- and sex-matched T2DM patients without CAD were included in the final analysis. Plasma ALKAL2 levels were increased in T2DM patients with CAD (0.25 [0.21, 0.37] ng/mL, median [IQR] vs. 0.18 [0.14, 0.24]ng/mL) (p < 0.001) and were positively associated with CAD severity (Spearman rho = 0.53, p < 0.001). Multivariate analysis revealed that plasma ALKAL2 levels were independently associated with the incidence of CAD after adjusting for LDL-C, hsCRP, and other traditional risk factors (OR, 2.24 [95% CI, 1.79-2.85]; p < 0.001).

Conclusions: Elevated plasma ALKAL2 levels are an independent risk factor for T2DM CAD and are associated with the severity of CAD.

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血浆碱2水平与2型糖尿病患者冠状动脉粥样硬化相关

背景：癌症相关的信号通路，特别是ALK/LTK受体酪氨酸激酶及其配体alk2，最近被认为与慢性炎症和心肌重构有关。然而，alk2与2型糖尿病（T2DM）冠状动脉疾病（CAD）发病机制之间的关系尚不清楚。方法：选取2019年1月至2020年12月瑞金医院行冠状动脉造影的2型糖尿病（T2DM）患者为研究对象。采用ELISA法测定血浆碱2水平。通过Spearman相关分析评估alalk2与冠心病严重程度之间的关系。使用Logistic回归模型来测量alalk2与CAD风险之间的关系。结果：275例合并CAD的T2DM患者和275例年龄和性别匹配的无CAD的T2DM患者被纳入最终分析。伴有冠心病的T2DM患者血浆alg2水平升高（0.25 [0.21,0.37]ng/mL，中位数[IQR] vs. 0.18 [0.14, 0.24]ng/mL） (p)。结论：血浆alg2水平升高是T2DM冠心病的独立危险因素，且与冠心病的严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Diabetology 医学-内分泌学与代谢

CiteScore

12.30

自引率

15.10%

发文量

240

审稿时长

1 months

期刊介绍： Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.