Propolis enhanced sodium alginate hydrogel enriched with copper doped mesoporous bioactive glass nanoparticles for advanced burn care applications.

IF 2.1 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology Letters Pub Date : 2025-10-09 DOI:10.1007/s10529-025-03662-9

Aqsa Aizaz, Muhammad Haseeb Nawaz, Muhammad Sameet Ismat, Md Abdur Rashid, Muhammad Atiq Ur Rehman

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引用次数: 0

Abstract

Chronic wounds, with prolonged healing time, remain a formidable challenge due to lack of angiogenesis, antimicrobial effect, and biocompatibility of conventional wound dressings. The current study focuses on developing novel copper-doped mesoporous bioactive glass nanoparticles (Cu-MBGNs) doped with Propolis/ Sodium Alginate (ALG) based hydrogel to promote angiogenesis, tissue regeneration, biocompatibility, and antimicrobial efficacy for advanced wound healing applications. Hydrogel was synthesized using a solution-casting method. It was characterized using material and biological characterization techniques. Scanning electron microscopy (SEM) displayed an interconnected porous network with dispersed Cu-MBGNs facilitating hydrogel swelling/deswelling and degradation behavior (75%). Fourier Transform Infrared Spectroscopy (FTIR) confirmed crosslinking between propolis and ALG via hydrogen bonding. Hydrogel exhibited an antimicrobial effect against Escherichia coli and Staphylococcus gallinarum. Cu⁺² promoted vasculogenesis by modulating vascular endothelial growth factor release and cytocompatibility. These results suggest that Propolis/ALG/Cu-MBGNs hydrogel offers cost-effective and sustainable solution for enhanced wound healing.

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蜂胶增强海藻酸钠水凝胶，富含铜掺杂的介孔生物活性玻璃纳米颗粒，用于高级烧伤护理应用。

由于传统伤口敷料缺乏血管生成、抗菌作用和生物相容性，慢性伤口愈合时间较长，仍然是一个巨大的挑战。目前的研究重点是开发新型的铜掺杂介孔生物活性玻璃纳米颗粒（Cu-MBGNs），并掺杂蜂胶/海藻酸钠（ALG）基水凝胶，以促进血管生成、组织再生、生物相容性和抗菌功效，用于高级伤口愈合。采用溶液浇铸法合成水凝胶。利用材料和生物表征技术对其进行了表征。扫描电镜（SEM）显示，分散的Cu-MBGNs形成了一个相互连接的多孔网络，促进了水凝胶的溶胀/溶胀和降解行为（75%）。傅里叶变换红外光谱（FTIR）证实蜂胶与ALG通过氢键交联。水凝胶对大肠杆菌和鸡状葡萄球菌具有抗菌作用。Cu+2通过调节血管内皮生长因子释放和细胞相容性促进血管发生。这些结果表明，蜂胶/ALG/Cu-MBGNs水凝胶为促进伤口愈合提供了经济、可持续的解决方案。

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来源期刊

Biotechnology Letters 工程技术-生物工程与应用微生物

CiteScore

5.90

自引率

3.70%

发文量

108

审稿时长

1.2 months

期刊介绍： Biotechnology Letters is the world’s leading rapid-publication primary journal dedicated to biotechnology as a whole – that is to topics relating to actual or potential applications of biological reactions affected by microbial, plant or animal cells and biocatalysts derived from them. All relevant aspects of molecular biology, genetics and cell biochemistry, of process and reactor design, of pre- and post-treatment steps, and of manufacturing or service operations are therefore included. Contributions from industrial and academic laboratories are equally welcome. We also welcome contributions covering biotechnological aspects of regenerative medicine and biomaterials and also cancer biotechnology. Criteria for the acceptance of papers relate to our aim of publishing useful and informative results that will be of value to other workers in related fields. The emphasis is very much on novelty and immediacy in order to justify rapid publication of authors’ results. It should be noted, however, that we do not normally publish papers (but this is not absolute) that deal with unidentified consortia of microorganisms (e.g. as in activated sludge) as these results may not be easily reproducible in other laboratories. Papers describing the isolation and identification of microorganisms are not regarded as appropriate but such information can be appended as supporting information to a paper. Papers dealing with simple process development are usually considered to lack sufficient novelty or interest to warrant publication.