A prospective cohort study of C-reactive protein as a marker of aspiration pneumonia in canine tick paralysis (Ixodes holocyclus).

IF 1.7 4区农林科学 Q2 VETERINARY SCIENCES

Australian Veterinary Journal Pub Date : 2025-10-08 DOI:10.1111/avj.70025

M S Hollindale, S Joslyn, A M Padula, J M Morton, R A Webster

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引用次数: 0

Abstract

Objective: To evaluate the diagnostic and prognostic utility of C-reactive protein (CRP) in dogs with tick paralysis, focusing on its relationship with thoracic radiographic severity scores (TRSS).

Methods: Twenty client-owned dogs presenting to a veterinary emergency hospital were enrolled. CRP concentrations, TRSS, white blood cell count, red blood cell count, vital signs and oxygenation indices were assessed for up to 72 hours from admission.

Results: Using a CRP cut-off of ≥20 mg/L, sensitivity and specificity estimates for detecting pneumonia were both 0.86 but imprecise (95% confidence interval [CI] 0.49-0.99, 95% CI 0.57-0.98 respectively). CRP was moderately correlated with TRSS (Spearman's ρ = 0.77, 95% CI 0.60-0.88, P < 0.001) and was negatively correlated with heart rate (r = -0.302, 95% CI -0.518 to -0.049, P = 0.02), SpO₂ (r = -0.342, 95% CI -0.550 to -0.094, P = 0.008) and the SpO2/FiO₂ ratio (r = -0.292, 95% CI -0.510 to -0.039, P = 0.025). TRSS was negatively correlated with total WBC count (ρ = -0.382, 95% CI -0.638 to -0.051, P = 0.026). There was no evidence that CRP differs by gait score or respiratory grade after accounting for TRSS. Temporal trends by case showed that CRP increases in parallel with worsening radiographic scores.

Conclusions: CRP is a valuable biomarker for pneumonia in dogs with tick paralysis in conjunction with other clinical indicators of pneumonia.

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c反应蛋白作为犬蜱麻痹吸入性肺炎标志物的前瞻性队列研究。

目的：评价c反应蛋白（CRP）在蜱麻痹犬中的诊断和预后价值，重点研究其与胸片严重程度评分（TRSS）的关系。方法：选取20只到兽医急救医院就诊的客户犬。入院后72小时内评估CRP浓度、TRSS、白细胞计数、红细胞计数、生命体征和氧合指数。结果：使用CRP临界值≥20mg /L，检测肺炎的敏感性和特异性估计均为0.86，但不精确（95%置信区间[CI] 0.49-0.99, 95% CI 0.57-0.98）。CRP与TRSS (Spearman’s ρ = 0.77, 95% CI 0.60 ~ 0.88, P = 2 （r = -0.342, 95% CI -0.550 ~ -0.094, P = 0.008）和SpO2/FiO2比值（r = -0.292, 95% CI -0.510 ~ -0.039, P = 0.025）有中度相关性。TRSS与总白细胞计数呈负相关（ρ = -0.382, 95% CI -0.638 ~ -0.051, P = 0.026）。在考虑TRSS后，没有证据表明CRP因步态评分或呼吸等级而不同。病例的时间趋势显示CRP升高与x线评分恶化平行。结论：CRP与其他肺炎临床指标一起是蜱麻痹犬肺炎的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Veterinary Journal 农林科学-兽医学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

18-36 weeks

期刊介绍： Over the past 80 years, the Australian Veterinary Journal (AVJ) has been providing the veterinary profession with leading edge clinical and scientific research, case reports, reviews. news and timely coverage of industry issues. AJV is Australia''s premier veterinary science text and is distributed monthly to over 5,500 Australian Veterinary Association members and subscribers.