Optimization of a collimator design for an epithermal neutron source based on ⁷Li (p,n) Be reaction and 2.5 MeV protons for BNCT.

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-10-04 DOI:10.1016/j.apradiso.2025.112230

Ha Shuai, Eszter Dian, Ferenc Mezei, Péter Sipos, Szabolcs Czifrus

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Abstract

This work optimized the beam shaping assembly (BSA) for a compact accelerator-based boron neutron capture therapy (AB-BNCT) system with a 2.5 MeV, 10 mA proton beam incident on a lithium target to generate fast neutrons. MgF₂ and Pb were selected as the moderator and reflector materials, respectively. The collimator consisting of a layer of Pb and a layer of ⁶Li enriched polyethylene is studied in detail. ⁶Li enriched PE has greater impact on neutron flux and the ratio of flux and current, and 2.2 cm is chosen to be the thickness of ⁶Li enriched PE layer. Furthermore, a modular collimator design is presented to adjust collimator diameter from 8 cm to 17 cm with a step of 1 cm for different head/neck tumor size and positions. The in-air beam characteristics meet the IAEA criteria published in 2001 and 2023. The in-phantom dose evaluation shows that, with similar beam characteristics, a larger beam diameter can deliver a higher dose rate and deeper advantage depth, double dose depth and triple dose depth.

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基于7Li (p,n) Be反应和2.5 MeV质子的超热中子源准直器设计优化。

本工作优化了基于加速器的紧凑型硼中子捕获治疗（AB-BNCT）系统的束整形组件（BSA），该系统将2.5 MeV， 10 mA质子束入射到锂靶上以产生快中子。选择MgF2和Pb分别作为慢化剂和反射材料。详细研究了由一层Pb和一层富集6Li的聚乙烯组成的准直器。6Li富集PE对中子通量和通量电流比的影响较大，6Li富集PE层厚度选择2.2 cm。此外，提出了一种模块化准直器设计，可以根据不同的头颈部肿瘤大小和位置，以1 cm的步长调整准直器直径从8 cm到17 cm。空气中光束特性满足2001年和2023年发布的IAEA标准。幻影内剂量评估表明，在光束特性相似的情况下，更大的光束直径可以提供更高的剂量率和更深的优势深度，双剂量深度和三剂量深度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.