Lin Yang, Lianyong Han, Otmar Schmid, Chunying Chen
{"title":"Precision dosimetry in pulmonary drug delivery","authors":"Lin Yang, Lianyong Han, Otmar Schmid, Chunying Chen","doi":"10.1038/s44222-025-00356-9","DOIUrl":null,"url":null,"abstract":"Nanotechnology-based platforms are being explored for the delivery of therapeutics directly to the lungs through inhalation. However, to ensure translational relevance between preclinical animal models and human applications, it is essential to accurately quantify and report the lung-deposited dose, rather than relying solely on the nominally administered dose.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"810-812"},"PeriodicalIF":37.6000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-025-00356-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Nanotechnology-based platforms are being explored for the delivery of therapeutics directly to the lungs through inhalation. However, to ensure translational relevance between preclinical animal models and human applications, it is essential to accurately quantify and report the lung-deposited dose, rather than relying solely on the nominally administered dose.
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