Antibacterial activity of Ag nanoparticles embedded tragacanth gum-based composite hydrogel synthesized with acrylamide and 2-acrylamido-2-methylpropanesulfonic acid

IF 4 3区化学 Q2 POLYMER SCIENCE

Polymer Bulletin Pub Date : 2025-07-09 DOI:10.1007/s00289-025-05895-0

Anuradha C. Hugar, Manjunath S.Hanagadakar, Jagadish N. Hiremath, Anjanapura V. Raghu

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Abstract

Ag nanoparticles (AgNPs) were successfully embedded into a tragacanth gum-based composite hydrogel, synthesized via free radical polymerization using acrylamide and 2-acrylamido-2-methylpropanesulfonic acid (AMPS). The resulting hydrogel exhibited enhanced thermal stability, as confirmed by thermogravimetric analysis, and a semi-crystalline structure observed in X-ray Diffraction analysis. Scanning electron microscope images revealed a uniform dispersion of AgNPs within the hydrogel matrix. Swelling studies revealed a maximum swelling ratio of 650% at pH 9.0 for the AgNPs-anchored hydrogel, significantly higher than the AgNP-free hydrogel. Elemental analysis indicated an Ag content of 7.2% by weight. Antibacterial assays demonstrated strong activity against both Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentration values of 2500 µg/mL and 19.53 µg/mL, respectively. These results highlight the potential of the developed mTG-g-p(Am-co-AMPS)-Ag nanocomposite hydrogel as an effective antibacterial material for biomedical and environmental applications.

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丙烯酰胺与2-丙烯酰胺-2-甲基丙磺酸复合水凝胶包埋银纳米颗粒的抗菌活性研究

以丙烯酰胺和2-丙烯酰胺-2-甲基丙磺酸（AMPS）为原料，通过自由基聚合法制备了银纳米粒子（AgNPs）。所得水凝胶表现出增强的热稳定性，经热重分析证实，并在x射线衍射分析中观察到半晶体结构。扫描电镜图像显示AgNPs在水凝胶基质内均匀分散。膨胀研究表明，在pH为9.0时，agnps锚定的水凝胶的最大膨胀率为650%，显著高于不含agnps的水凝胶。元素分析表明其银含量为7.2%（重量计）。对大肠杆菌和金黄色葡萄球菌均有较强的抑菌活性，最低抑菌浓度分别为2500µg/mL和19.53µg/mL。这些结果突出了所开发的mTG-g-p(Am-co-AMPS)-Ag纳米复合水凝胶作为生物医学和环境应用的有效抗菌材料的潜力。

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."