Unidirectional drug release controlled by a PLA/mesoporous bioactive glass/PVA polymer composite

IF 4 3区化学 Q2 POLYMER SCIENCE

Polymer Bulletin Pub Date : 2025-07-25 DOI:10.1007/s00289-025-05954-6

Lijun Ji, Chendi Wang, Fengjuan Chen, Chunyu Xie, Xiang Qin, Xiaojun Yang

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Abstract

A polymer composite based on PLA/MBGs-LVFX/PVA with unidirectional drug release property was prepared with mesoporous bioactive glasses (MBGs) as a drug-loading layer, polylactic acid (PLA) as a barrier layer, and polyvinyl alcohol (PVA) as a controlled release layer. The Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, thermogravimetric analysis, and small-angle X-ray scattering were employed to characterize the composition and structure of the PLA/MBGs-LVFX/PVA unidirectional drug release system. Nitrogen absorption characterization confirmed that the specific surface area of MBGs reached 485.6 m²/g with an average pore diameter of 6 nm. The PLA/MBGs-LVFX/PVA polymer composite exhibited a levofloxacin hydrochloride (LVFX) loading capacity of 41.17%, an encapsulation efficiency of 66.5%, and a cumulative release rate reaching 61.28% within 24 h, demonstrating excellent drug loading and release capabilities. The mechanism by which PVA controlled the release of LVFX was discussed. The biodegradation of the drug release system in PBS led to a certain increase in pH, which is conducive to bactericidal efficacy. In vitro bioactivity assessment confirmed that this drug release system had no significant cytotoxicity at a reasonable dosage. This unidirectional drug release film is expected to achieve targeted drug delivery to focal sites rich in sensitive nerves, thereby improving drug efficacy and reducing side effects on the nervous system.

Graphical abstract

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聚乳酸/介孔生物活性玻璃/聚乙烯醇聚合物复合材料控制药物单向释放

以介孔生物活性玻璃（MBGs）为载药层，聚乳酸（PLA）为阻隔层，聚乙烯醇（PVA）为控释层，制备了具有单向释药性能的PLA/MBGs- lvfx /PVA聚合物复合材料。采用傅里叶变换红外光谱、透射电镜、扫描电镜、热重分析和小角度x射线散射等方法对PLA/MBGs-LVFX/PVA单向释药体系的组成和结构进行表征。氮吸收表征证实MBGs的比表面积达到485.6 m2/g，平均孔径为6 nm。PLA/MBGs-LVFX/PVA聚合物复合材料的载药量为41.17%，包封效率为66.5%，24 h内的累积释放率为61.28%，具有良好的载药量和释放能力。讨论了PVA控制LVFX释放的机理。药物释放系统在PBS中生物降解，导致pH值有一定的升高，有利于杀菌效果。体外生物活性评价证实该释药体系在合理剂量下无明显细胞毒性。这种单向药物释放膜有望实现药物靶向递送到富含敏感神经的病灶部位，从而提高药物疗效，减少对神经系统的副作用。图形抽象

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."