Preparation of cobalt porphyrin-based covalent organic framework doped poly(deep eutectic solvent-co-ethylene glycol dimethacrylate) monolithic column for pipette tip micro solid-phase extraction of estrogens

IF 6 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2025-10-09 DOI:10.1016/j.aca.2025.344760

Wenjun Wang , Hui Lyu , Caisa Xiao , Jie Zhu , Huaixia Chen , Qian Chen , Xueping Dang

{"title":"Preparation of cobalt porphyrin-based covalent organic framework doped poly(deep eutectic solvent-co-ethylene glycol dimethacrylate) monolithic column for pipette tip micro solid-phase extraction of estrogens","authors":"Wenjun Wang , Hui Lyu , Caisa Xiao , Jie Zhu , Huaixia Chen , Qian Chen , Xueping Dang","doi":"10.1016/j.aca.2025.344760","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Estrogens are representative endocrine-disrupting chemicals that enter the environment through various pathways and pose detrimental impacts to human health even at low concentrations. Therefore, the highly sensitive detection of estrogens in complex environmental samples is crucial.</div></div><div><h3>Results</h3><div>A cobalt porphyrin-based covalent organic framework (Co-Por-COF) doped polymer monolithic column for pipette tip micro-solid phase extraction (PT-μSPE) of estrogens was prepared using deep eutectic solvent composed of choline chloride (ChCl) and itaconic acid (IA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent. After the extraction conditions were optimized, a PT-μSPE-high performance liquid chromatography (HPLC) method was established for the detection of 6 estrogens in soil. This method demonstrated a wide linear range (5−500 ng g<sup>−1</sup>) (<em>R</em><sup>2</sup> > 0.9995), low limits of detection (0.5−1.0 ng g<sup>−1</sup>, S/N = 3) and high precision (RSDs <8.5 %), providing a reliable technique for the detection of trace estrogens in soil.</div></div><div><h3>Significance</h3><div>The Co-Por-COF doped poly (ChCl-IA-co-EGDMA) monolithic column exhibited good adsorption selectivity for estrogens. During the polymerization reaction, ChCl-IA effectively enhanced the dispersibility of Co-Por-COF, thereby improving the doping uniformity. Moreover, the doped Co-Por-COF enhanced the adsorption performance of the monolithic column for estrogens.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1380 ","pages":"Article 344760"},"PeriodicalIF":6.0000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003267025011547","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Estrogens are representative endocrine-disrupting chemicals that enter the environment through various pathways and pose detrimental impacts to human health even at low concentrations. Therefore, the highly sensitive detection of estrogens in complex environmental samples is crucial.

Results

A cobalt porphyrin-based covalent organic framework (Co-Por-COF) doped polymer monolithic column for pipette tip micro-solid phase extraction (PT-μSPE) of estrogens was prepared using deep eutectic solvent composed of choline chloride (ChCl) and itaconic acid (IA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent. After the extraction conditions were optimized, a PT-μSPE-high performance liquid chromatography (HPLC) method was established for the detection of 6 estrogens in soil. This method demonstrated a wide linear range (5−500 ng g⁻¹) (R² > 0.9995), low limits of detection (0.5−1.0 ng g⁻¹, S/N = 3) and high precision (RSDs <8.5 %), providing a reliable technique for the detection of trace estrogens in soil.

Significance

The Co-Por-COF doped poly (ChCl-IA-co-EGDMA) monolithic column exhibited good adsorption selectivity for estrogens. During the polymerization reaction, ChCl-IA effectively enhanced the dispersibility of Co-Por-COF, thereby improving the doping uniformity. Moreover, the doped Co-Por-COF enhanced the adsorption performance of the monolithic column for estrogens.

Abstract Image

查看原文本刊更多论文

制备卟啉钴基共价有机骨架掺杂聚（深共溶溶剂-共乙二醇二甲基丙烯酸酯）整体柱，用于移液管尖端微固相萃取雌激素

破坏者是具有代表性的内分泌干扰化学物质，通过各种途径进入环境，即使浓度很低也会对人体健康造成有害影响。因此，在复杂环境样品中进行高灵敏度的雌激素检测是至关重要的。结果以氯化胆碱（ChCl）和衣通酸（IA）为功能单体，乙二醇二甲基丙烯酸酯（EGDMA）为交联剂，制备了基于钴卟啉的共价有机骨架（Co-Por-COF）掺杂聚合物整体柱，用于移管尖微固相萃取（PT-μSPE）雌激素。对提取条件进行优化后，建立了PT-μ spe -高效液相色谱法检测土壤中6种雌激素的方法。该方法线性范围宽（5 ~ 500 ng g−1）（R2 > 0.9995），检出限低（0.5 ~ 1.0 ng g−1,S/N=3），精密度高（rsd < 8.5%），为土壤中痕量雌激素的检测提供了可靠的方法。意义Co-Por-COF掺杂聚（ChCl-IA-co-EGDMA）整体柱对雌激素具有良好的吸附选择性。在聚合反应过程中，ChCl-IA有效地增强了co - poro - cof的分散性，从而提高了掺杂均匀性。此外，掺杂的co - poro - cof增强了整体柱对雌激素的吸附性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.