Electrochemical Tandem Cyclization of N‐(But‐3‐en‐1‐yl)Anilines to Access Trifluoromethylated Tetrahydroquinoline Derivatives

Abstract

A novel electrochemical cascade strategy enables dual CC bond formation through trifluoromethylation and C(sp2)‐H functionalization of N‐(but‐3‐en‐1‐yl)anilines derivatives. This protocol efficiently constructs structurally diverse trifluoromethylated tetrahydroquinoline derivatives in moderate to good yields. It operates under mild reaction conditions, uses readily available substrates, proceeds without metal catalysts, and achieves the construction of two CC bonds in a single step. Detailed mechanistic studies demonstrate that a sequential single‐electron transfer (SET) process triggers the radical cascade reaction.