Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model.

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology Pub Date : 2025-10-07 DOI:10.1016/j.jaci.2025.09.009

Tommaso Marchetti,Samantha Milanesi,Diana Tintor,Julius Köppen,Tiziana Lorenzini,Severin Walser,Stefano Vavassori,Onur Boyman,Jana Pachlopnik Schmid

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选择性IL-2递送调节人HLH中的CD8+ T细胞并改善小鼠模型中的疾病特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.