SMART v10: three decades of the protein domain annotation resource.

IF 13.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleic Acids Research Pub Date : 2025-10-08 DOI:10.1093/nar/gkaf1023

Ivica Letunic,Peer Bork

引用次数: 0

Abstract

SMART (Simple Modular Architecture Research Tool, https://smart.embl.de) is a web-based platform for identifying and annotating protein domains and analyzing domain architectures. SMART version 10 features manually curated models for over 1300 protein domains. Approaching its 30th anniversary, SMART's user interface has been redesigned from the ground up, leveraging modern web technologies to enhance intuitiveness and usability. SMART's "Genomic" mode, which annotates proteins from completely sequenced genomes was synchronized with the current release of STRING, and now includes 12 035 species, compared to 5090 in the previous release. Protein and domain annotation pages have been updated with new information sources. Integration with eggNOG provides links to 17.5 million orthologous groups for over 53 million proteins. Additionally, synchronization with the interactive Pathways Explorer version 3 incorporates updated KEGG pathway and orthologous group data, enabling direct visualization on four distinct pathway overview maps.

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SMART v10：三十年的蛋白质结构域注释资源。

SMART （Simple Modular Architecture Research Tool, https://smart.embl.de）是一个基于web的识别和注释蛋白质结构域和分析结构域架构的平台。SMART版本10功能手动策划模型超过1300个蛋白质域。接近30周年，SMART的用户界面已经重新设计，利用现代网络技术，以提高直观性和可用性。SMART的“基因组”模式，对完全测序的基因组中的蛋白质进行注释，与当前版本的STRING同步，现在包括12035个物种，而之前版本只有5090个。蛋白质和结构域注释页面已经更新了新的信息源。与eggNOG的整合为超过5300万个蛋白质提供了1750万个同源基团的链接。此外，与交互式路径资源管理器版本3的同步包含了更新的KEGG路径和同源组数据，可以在四个不同的路径概览图上直接可视化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.