Low dose oral semaglutide for obesity . . . and other research

Abstract

Tom Nolan reviews this week’s research Multicancer detection (MCD) tests are available to buy—although may set you back more than a thousand pounds. Websites offering the tests, that usually detect fragments of DNA released by cancer cells, seem to imply an established evidence base for them, such as that they’ve been validated on over 40 000 participants. A systematic review suggests there is still a way to go: the authors searched for controlled studies in screening populations and found no controlled studies that report benefits of screening with MCD tests. The NHS-Galleri trial should change that and is expected to report its findings next year. Ann Intern Med doi:10.7326/ANNALS-25-01877 Countless headlines exalt the life changing benefits of newer …