Hourly exposure to ambient air pollutants and risk of acute aortic dissection: Evidence from 162 Chinese cities.

IF 1.4

Journal of occupational and environmental medicine Pub Date : 2025-10-08 DOI:10.1097/JOM.0000000000003574

Zhenyu Liu, Shuangyue Qian, Kai Ren, Ruxing Wan, Ling Tang, Xiangyu Chang

{"title":"Hourly exposure to ambient air pollutants and risk of acute aortic dissection: Evidence from 162 Chinese cities.","authors":"Zhenyu Liu, Shuangyue Qian, Kai Ren, Ruxing Wan, Ling Tang, Xiangyu Chang","doi":"10.1097/JOM.0000000000003574","DOIUrl":null,"url":null,"abstract":"Objective: To examine the association between hourly spikes in air pollutant exposure and the risk of acute aortic dissection (AAD) onset.Methods: This time-stratified case-crossover study analyzed a national Chinese registry of 3,125 AAD cases across 162 cities. Piecewise conditional logistic regression and distributed lag nonlinear models were used to estimate relative risks (RRs) and 95% confidence intervals.Results: Increases in PM10 (RR = 1.019 per 10 μg/m3) and CO (RR = 1.184 per 1 mg/m3) were associated with higher AAD risk. Exposure above thresholds yielded increased risks for PM2.5 > 200 μg/m3 (RR = 1.074 per 10 μg/m3) and NO2 > 100 μg/m3 (RR = 1.065 per μg/m3). Effects showed lagged patterns for CO and PM10. Males, older adults, hypertensive patients, smokers, and overweight individuals showed greater susceptibility.Conclusions: This study provides the first evidence that hourly air pollution spikes significantly increase AAD risk, supporting targeted public health measures.","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of occupational and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JOM.0000000000003574","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To examine the association between hourly spikes in air pollutant exposure and the risk of acute aortic dissection (AAD) onset.

Methods: This time-stratified case-crossover study analyzed a national Chinese registry of 3,125 AAD cases across 162 cities. Piecewise conditional logistic regression and distributed lag nonlinear models were used to estimate relative risks (RRs) and 95% confidence intervals.

Results: Increases in PM10 (RR = 1.019 per 10 μg/m3) and CO (RR = 1.184 per 1 mg/m3) were associated with higher AAD risk. Exposure above thresholds yielded increased risks for PM2.5 > 200 μg/m3 (RR = 1.074 per 10 μg/m3) and NO2 > 100 μg/m3 (RR = 1.065 per μg/m3). Effects showed lagged patterns for CO and PM10. Males, older adults, hypertensive patients, smokers, and overweight individuals showed greater susceptibility.

Conclusions: This study provides the first evidence that hourly air pollution spikes significantly increase AAD risk, supporting targeted public health measures.

查看原文本刊更多论文

每小时暴露于环境空气污染物与急性主动脉夹层风险：来自162个中国城市的证据

目的：探讨空气污染物暴露小时峰值与急性主动脉夹层（AAD）发病风险的关系。方法：这项时间分层的病例交叉研究分析了中国162个城市的3125例AAD病例。使用分段条件逻辑回归和分布滞后非线性模型估计相对风险（rr）和95%置信区间。结果：PM10 （RR = 1.019 / 10 μg/m3）和CO （RR = 1.184 / 1 mg/m3）升高与AAD风险升高相关。暴露于阈值以上，PM2.5浓度为200 μg/m3 (RR = 1.074 / 10 μg/m3)， NO2浓度为100 μg/m3 （RR = 1.065 / μg/m3）的风险增加。对CO和PM10的影响呈现滞后模式。男性、老年人、高血压患者、吸烟者和超重个体表现出更高的易感性。结论：本研究提供了第一个证据，表明每小时空气污染峰值显著增加AAD风险，支持有针对性的公共卫生措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of occupational and environmental medicine

自引率

0.00%

发文量