Expression of hox Genes and Genes Related to Limb Development During the Homeotic Transformation of Tails Into Limbs Induced by Vitamin A in the Anuran Rana ornativentris.
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Abstract
Anuran tadpoles regenerate their tails after amputation. However, when vitamin A is administered, some anuran species such as Rana ornativentris occasionally form ectopic limbs instead of tail. Few analyses of this phenomenon at the molecular level exist. To investigate the molecular mechanisms underlying ectopic limb development, we quantified the expression of genes related to normal limb positioning and development. We observed the downregulation of a posterior hox gene prior to the appearance of ectopic limb buds in the regenerating tail. This hox expression change also preceded the upregulation of pitx1, which is expressed in the earliest hind limb bud. These results suggest that Hox genes are involved in ectopic limb induction upstream of hind limb genes.
期刊介绍：
Development Growth & Differentiation (DGD) publishes three types of articles: original, resource, and review papers.
Original papers are on any subjects having a context in development, growth, and differentiation processes in animals, plants, and microorganisms, dealing with molecular, genetic, cellular and organismal phenomena including metamorphosis and regeneration, while using experimental, theoretical, and bioinformatic approaches. Papers on other related fields are also welcome, such as stem cell biology, genomics, neuroscience, Evodevo, Ecodevo, and medical science as well as related methodology (new or revised techniques) and bioresources.
Resource papers describe a dataset, such as whole genome sequences and expressed sequence tags (ESTs), with some biological insights, which should be valuable for studying the subjects as mentioned above.
Submission of review papers is also encouraged, especially those providing a new scope based on the authors’ own study, or a summarization of their study series.
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