Unlocking IL-18: A hidden key in cancer immunity

IF 11.5 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI:10.1016/j.smim.2025.101997

Shima Sepehri-Manesh , Marion Debeaud , Valerie Vouret-Craviari

引用次数: 0

Abstract

The IL-1 family comprises 11 cytokines, including IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33, and IL-36 cytokines to IL-37 and IL-38, that modulate innate immune system activity. In addition to their role in innate immunity, IL-1 family members can activate and enhance the function of polarized T cells. For example, IL-33 primarily influences T helper 2 (T_H2) cells, IL-1 plays a central role in the differentiation of T_H17 cells, and IL-18 predominantly affects T_H1 cells. The IL-1 family members participated in various biological functions as described elsewhere in this special issue. Here, we provide an overview on IL-18, originally called IFN-γ inducing factor, and its role in impacting cancer immunity.

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解锁IL-18：癌症免疫的隐藏钥匙

IL-1家族包括11种细胞因子，包括IL-1α、IL-1β、IL-1受体拮抗剂（IL-1Ra）、IL-18、IL-33和IL-36到IL-37和IL-38，它们调节先天免疫系统的活性。除了在先天免疫中发挥作用外，IL-1家族成员还可以激活和增强极化T细胞的功能。例如，IL-33主要影响T辅助2 （TH2）细胞，IL-1在TH17细胞的分化中起核心作用，IL-18主要影响TH1细胞。IL-1家族成员参与了本特刊其他地方描述的各种生物学功能。在这里，我们概述了IL-18，最初被称为IFN-γ诱导因子，及其在影响癌症免疫中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.