A systematic review and meta-analysis of clinical trials on lavender for sleep disorders in the elderly.

IF 4.3

Experimental gerontology Pub Date : 2025-10-05 DOI:10.1016/j.exger.2025.112919

Mohadeseh Ostovar, Mohammad Hamed Khademizadeh, Foroogh Namjoyan, Asma Kazemi, Sina Vakili, Seyed Hamdollah Mosavat, Mohsen Mohit, Mohammad Hashem Hashempur

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Abstract

Background: The present study aimed to gather existing findings related to the effect of lavender on improving sleep disorders in older adults.

Methods: In this systematic review, PubMed, Web of Science, Embase, and Scopus databases were searched using keywords ((lavender OR Lavandula) AND (sleep OR insomnia OR "sleep disturbance" OR "sleep quality" OR "sleep disorder") AND (elderly OR elder OR aging OR aging OR "older adult" OR geriatric OR geriatrics)) from their inception up to August 20, 2025. Only clinical trials evaluating the effect of lavender on aged patients (more than 60 years old) with sleep disorders were included. Then, data about drug formulation, dosage, duration of treatment, measurements, findings, and adverse events were recorded. A random-effects meta-analysis was used to calculate the pooled standardized mean differences (SMD) and their corresponding 95 % confidence intervals (CI).

Results: In this study, 84 articles were evaluated, and ten articles were selected for full review. In nine studies (90 %), lavender significantly improved sleep disorders. The most used scale among the articles was the Pittsburgh Sleep Quality Index (PSQI), which was used in seven studies (70 %). All the studies reported using lavender in the medicinal form of inhalation. The results of the meta-analysis indicated a significant improvement in the total score of sleep quality (SMD: -1.20, 95 % CI: -1.73, -0.68, I²: 87.5 %), with a more pronounced effect observed in studies that utilized the PSQI questionnaire.

Conclusion: Based on preliminary evidence from this review, lavender may effectively treat sleep disorders, especially in the elderly. However, more research is required to fully understand its effectiveness and safety, especially with long-term use.

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薰衣草治疗老年人睡眠障碍临床试验的系统回顾和荟萃分析。

背景：本研究旨在收集与薰衣草改善老年人睡眠障碍有关的现有发现。方法：在本系统综述中，检索PubMed、Web of Science、Embase和Scopus数据库，检索关键词为（lavender OR Lavandula）、（sleep OR insomnia OR“睡眠障碍”OR“睡眠质量”OR“睡眠障碍”）和（elderly OR elder OR aging OR aging OR“older adult”OR geriatric OR geriatrics），检索时间截止至2025年8月20日。仅包括评估薰衣草对老年睡眠障碍患者（60岁以上 岁）影响的临床试验。然后，记录有关药物配方、剂量、治疗时间、测量、结果和不良事件的数据。采用随机效应荟萃分析计算合并标准化平均差异（SMD）及其相应的95% %置信区间（CI）。结果：本研究共评估84篇文章，选取10篇文章进行全面综述。在9项研究中（90% %），薰衣草显著改善了睡眠障碍。文章中使用最多的量表是匹兹堡睡眠质量指数（PSQI），在7项研究中使用（70% %）。所有的研究都报道了薰衣草以吸入的药物形式使用。荟萃分析结果显示，睡眠质量总分显著改善（SMD: -1.20, 95 % CI: -1.73, -0.68, I2: 87.5 %），在使用PSQI问卷的研究中观察到更明显的效果。结论：基于本综述的初步证据，薰衣草可能有效治疗睡眠障碍，特别是老年人。然而，需要更多的研究来充分了解其有效性和安全性，特别是长期使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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