Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study.

IF 1.3 4区医学 Q3 PEDIATRICS

Archives De Pediatrie Pub Date : 2025-10-06 DOI:10.1016/j.arcped.2025.08.004

Hamdy El-Sayed, Hala Elmarsafawy, Basma Shouman, Mostafa Mansour, Amal Osman

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引用次数: 0

Abstract

Background: Pediatric pulmonary arterial hypertension (PAH) is a potentially fatal disease. New targeted therapies based on the underlying pathogenesis are still needed.

Objective: This study aims to evaluate the role of leukotriene E4, an inflammatory mediator, in developing pediatric pulmonary arterial hypertension (PAH).

Methods and setting: The study included 21 patients with PAH who belonged to group 1 of the international pH classification. PAH was diagnosed via cardiac catheterization. Most patients had PAH associated with congenital heart disease (PAHCHD). The control group comprised 21 healthy participants of matched age and sex. Urinary leukotriene E4 (LTE4) levels were assessed using an enzyme-linked immunosorbent assay.

Results: Urinary LTE4 levels and urinary LTE4 to urinary creatinine ratio were significantly increased among patients compared to healthy controls (p < 0.05). Further, a high combination of sensitivity and specificity was observed for urinary LTE4 with a cut-off level of 35.4pg/ml for predicting PAH.

Conclusion: The significantly elevated urinary LTE4 levels in pediatric patients with PAH can suggest the role of LTE4 as an inflammatory mediator in the disease pathogenesis.

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尿白三烯E4在小儿肺动脉高压中的应用：一项初步病例对照研究。

背景：小儿肺动脉高压（PAH）是一种潜在的致命性疾病。目前仍需要基于潜在发病机制的新的靶向治疗方法。目的：本研究旨在评估炎症介质白三烯E4在儿童肺动脉高压（PAH）发生中的作用。方法与背景：本研究纳入21例PAH患者，属于国际pH分类1组。经心导管诊断为PAH。多数患者伴有先天性心脏病（PAHCHD）。对照组由21名年龄和性别相匹配的健康参与者组成。尿白三烯E4 （LTE4）水平采用酶联免疫吸附法评估。结果：患者尿LTE4水平及尿LTE4 /尿肌酐比值均显著高于健康对照组（p < 0.05）。此外，尿LTE4具有较高的敏感性和特异性，预测PAH的截止水平为35.4pg/ml。结论：小儿PAH患者尿LTE4水平显著升高，提示LTE4在PAH发病机制中发挥炎症介质的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.