{"title":"Comparative Diagnostic Accuracy of Pleural Effusion Classification Methods in Cats: An Analysis of Naturally Occurring Cases.","authors":"A Mazzei, F Busato, G Marceglia, A Zoia","doi":"10.1111/vcp.70059","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pleural effusion (PE) in cats can result from transudative or exudative processes. Transudates are caused by decreased colloid osmotic pressure (↓COP) or elevated hydrostatic pressure (↑HP) gradient, while exudates arise from increased pleural capillary permeability. Diagnostic classification approaches traditionally rely on pleural effusion total protein (TP<sub>PE</sub>) and total nucleated cell counts (TNCC<sub>PE</sub>). In contrast, Light's criteria employing pleural effusion lactate dehydrogenase (LDH<sub>PE</sub>), LDH<sub>PE</sub> divided by serum LDH (LDH<sub>ratio</sub>), and pleural effusion to serum protein ratio (TP<sub>ratio</sub>) are more accurate than classification based on TP<sub>PE</sub>/TNCC<sub>PE</sub> in humans and show promise in cats.</p><p><strong>Objectives: </strong>To assess the diagnostic accuracy of TNCC<sub>PE</sub>, LDH<sub>PE</sub>, LDH<sub>ratio</sub>, TP<sub>PE</sub>, and TP<sub>ratio</sub> in classifying feline PEs in ↑HP-transudates, ↓COP-transudates, or exudates and to compare simplified Light's criteria (which relies solely on LDH<sub>PE</sub>) with Light's criteria and existing veterinary classification schemes based on TP<sub>PE</sub> and TNCC<sub>PE</sub> (named Vet-A and Vet-B).</p><p><strong>Methods: </strong>Cross-sectional study including 83 client-owned cats with PE.</p><p><strong>Results: </strong>There were 55 exudates, 28 ↑HP-transudates, and 0 ↓COP-transudates. All the variables analyzed were significantly different between exudates and transudates. Simplified Light's criteria correctly classified 50/55 exudates and 26/28 ↑HP-transudates (sensitivity = 91%, specificity = 93%, accuracy = 92%). Light's criteria correctly identified 55/55 exudates but misclassified 15/28 ↑HP-transudates as exudates (accuracy = 82%). Traditional veterinary schemes showed lower accuracies: Vet-A (57%) and Vet-B (74%). Simplified Light's criteria outperformed Vet-A (p < 0.001) and Vet-B (p = 0.007) and trended higher than Light's criteria (p = 0.096).</p><p><strong>Conclusions: </strong>Simplified Light's criteria demonstrate excellent diagnostic accuracy, outperforming traditional veterinary classification schemes.</p>","PeriodicalId":23593,"journal":{"name":"Veterinary clinical pathology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary clinical pathology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vcp.70059","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Pleural effusion (PE) in cats can result from transudative or exudative processes. Transudates are caused by decreased colloid osmotic pressure (↓COP) or elevated hydrostatic pressure (↑HP) gradient, while exudates arise from increased pleural capillary permeability. Diagnostic classification approaches traditionally rely on pleural effusion total protein (TPPE) and total nucleated cell counts (TNCCPE). In contrast, Light's criteria employing pleural effusion lactate dehydrogenase (LDHPE), LDHPE divided by serum LDH (LDHratio), and pleural effusion to serum protein ratio (TPratio) are more accurate than classification based on TPPE/TNCCPE in humans and show promise in cats.
Objectives: To assess the diagnostic accuracy of TNCCPE, LDHPE, LDHratio, TPPE, and TPratio in classifying feline PEs in ↑HP-transudates, ↓COP-transudates, or exudates and to compare simplified Light's criteria (which relies solely on LDHPE) with Light's criteria and existing veterinary classification schemes based on TPPE and TNCCPE (named Vet-A and Vet-B).
Methods: Cross-sectional study including 83 client-owned cats with PE.
Results: There were 55 exudates, 28 ↑HP-transudates, and 0 ↓COP-transudates. All the variables analyzed were significantly different between exudates and transudates. Simplified Light's criteria correctly classified 50/55 exudates and 26/28 ↑HP-transudates (sensitivity = 91%, specificity = 93%, accuracy = 92%). Light's criteria correctly identified 55/55 exudates but misclassified 15/28 ↑HP-transudates as exudates (accuracy = 82%). Traditional veterinary schemes showed lower accuracies: Vet-A (57%) and Vet-B (74%). Simplified Light's criteria outperformed Vet-A (p < 0.001) and Vet-B (p = 0.007) and trended higher than Light's criteria (p = 0.096).
期刊介绍：
Veterinary Clinical Pathology is the official journal of the American Society for Veterinary Clinical Pathology (ASVCP) and the European Society of Veterinary Clinical Pathology (ESVCP). The journal''s mission is to provide an international forum for communication and discussion of scientific investigations and new developments that advance the art and science of laboratory diagnosis in animals. Veterinary Clinical Pathology welcomes original experimental research and clinical contributions involving domestic, laboratory, avian, and wildlife species in the areas of hematology, hemostasis, immunopathology, clinical chemistry, cytopathology, surgical pathology, toxicology, endocrinology, laboratory and analytical techniques, instrumentation, quality assurance, and clinical pathology education.
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