Mathias Holm, Linus Schioler, Anna Dahlman-Hoglund, Håkan Tinnerberg, Martin Andersson, Annelie Behndig, Anders Blomberg, Kerstin Cederlund, Jonas Eriksson Ström, Christer Janson, Åse Johnsson, Eva Lindberg, Anders Lindén, Stefan Ljunggren, Andrei Malinovschi, Anna-Carin Olin, Ida Pesonen, Magnus Sköld, Magnus Svartengren, Hanan Tanash, Per Wollmer, Xi-Ming Yuan, Suneela Zaigham, Kjell Torén
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引用次数: 0
Abstract
Objectives: There is a lack of knowledge about whether occupational exposures increase the risk of emphysema, especially in never-smokers. Our objective was to determine if occupational exposures are associated with emphysema and impaired diffusing capacity.
Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS), persons from the general population aged 50-64 answered a questionnaire and underwent CT of the lung as well as assessment of the diffusing capacity of their lungs for carbon monoxide (DLCO), presented as DLCO
Results: In this cross-sectional study (27 370 persons including 13 981 never-smokers), occupational exposure to inorganic dust was associated with emphysema (OR 1.25, 95% CI 1.07 to 1.47), also among never-smokers, (OR 1.46, 95% CI 1.00 to 2.11). There were associations with DLCOCOCO, there was an association with inorganic dust (OR 1.65, 95% CI 1.20 to 2.28), also among never-smokers (OR 3.79, 95% CI 1.35 to 10.63).
Conclusions: Occupational exposures to inorganic dust are associated with emphysema. The association is stronger in those with the combination of emphysema and impaired DLCO indicating serious exposure effects in the alveoli.
目的：关于职业暴露是否会增加肺气肿的风险，特别是在从不吸烟的人群中，目前还缺乏相关知识。我们的目的是确定职业暴露是否与肺气肿和弥散能力受损有关。方法：在瑞典心肺生物图像研究（SCAPIS）中，来自50-64岁的普通人群的人回答了一份问卷，接受了肺部CT检查，并评估了他们的肺对一氧化碳（DLCO）的扩散能力（DLCO）。在这项横断面研究中（27370人，包括13981名从不吸烟者），职业性接触无机粉尘与肺气肿相关（OR 1.25, 95% CI 1.07至1.47），在从不吸烟者中也是如此（OR 1.46, 95% CI 1.00至2.11）。与DLCOCOCO相关，与无机粉尘相关（OR 1.65, 95% CI 1.20至2.28），也与不吸烟者相关（OR 3.79, 95% CI 1.35至10.63）。结论：职业性接触无机粉尘与肺气肿有关。在肺气肿和DLCO受损合并的患者中，这种关联更强，表明肺泡中有严重的暴露效应。
期刊介绍：
Occupational and Environmental Medicine is an international peer reviewed journal covering current developments in occupational and environmental health worldwide. Occupational and Environmental Medicine publishes high-quality research relating to the full range of chemical, physical, ergonomic, biological and psychosocial hazards in the workplace and to environmental contaminants and their health effects. The journal welcomes research aimed at improving the evidence-based practice of occupational and environmental research; including the development and application of novel biological and statistical techniques in addition to evaluation of interventions in controlling occupational and environmental risks.
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