Effects of Curcuminoids Plus Piperine Co-Supplementation on Serum Lipid Profile in Adults: A Systematic Review and Meta-Analysis of RCTs.

IF 1.6 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lipids Pub Date : 2025-10-07 DOI:10.1002/lipd.70004
Mehdi Karimi, Meysam Javadi, Maryam Sharifi, Kimia Kazemi, Sharareh Jahangiri, Niyousha Shirsalimi, Omid Asbaghi, Minoo Bassami
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引用次数: 0

Abstract

Dyslipidemia is a known risk factor for cardiovascular diseases (CVD). Research indicates that curcuminoids plus piperine co-supplementation (Curc + Pipe) can alter serum lipids. However, the findings from various studies are inconsistent. This meta-analysis aims to evaluate the efficacy of Curc + Pipe in serum lipid parameters in adults. A systematic search was conducted in databases until August 2025 to identify eligible randomized controlled trials (RCTs). To estimate the pooled effect size, weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were calculated, applying a random-effects model to account for potential variability between studies. A pooled analysis of 16 RCTs, encompassing a total of 1038 participants (Intervention: 522, Control: 516) revealed that Curc + Pipe significantly reduced triglycerides (TG) (WMD: -18.64 mg/mL, 95% CI: -29.94, -7.34, p < 0.001) and total cholesterol (TC) (WMD: -6.58 mg/mL, 95% CI: -12.60, -0.55, p = 0.032) and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 1.51 mg/mL, 95% CI: 0.29, 2.72, p = 0.015). However, the reduction in low-density lipoprotein cholesterol (LDL-C) was not statistically significant (WMD: -2.20 mg/mL, 95% CI: -7.22, 2.80, p = 0.387). Curc + Pipe has clinically meaningful lipid-modulating effects, particularly in reducing TG and TC and modestly increasing HDL-C levels. These benefits were most pronounced in more prolonged supplementation in individuals with dyslipidemia, metabolic disorders, and overweight. Clinically, Curc + Pipe may serve as a valuable complementary therapy for dyslipidemia management to decrease the risk of CVD.

姜黄素和胡椒碱共同补充对成人血脂的影响:随机对照试验的系统回顾和荟萃分析
血脂异常是已知的心血管疾病(CVD)危险因素。研究表明,姜黄素与胡椒碱共同补充(Curc + Pipe)可以改变血脂。然而,各种研究的结果并不一致。本荟萃分析旨在评估Curc + Pipe对成人血脂参数的影响。系统检索数据库直至2025年8月,以确定符合条件的随机对照试验(rct)。为了估计合并效应大小,计算加权平均差异(wmd)和相应的95%置信区间(ci),应用随机效应模型来解释研究之间的潜在变异性。一项包含1038名参与者的16项随机对照试验(干预:522,对照组:516)的汇总分析显示,Curc + Pipe显著降低了甘油三酯(TG) (WMD: -18.64 mg/mL, 95% CI: -29.94, -7.34, p
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来源期刊
Lipids
Lipids 生物-生化与分子生物学
CiteScore
4.20
自引率
5.30%
发文量
33
审稿时长
4-8 weeks
期刊介绍: Lipids is a journal of the American Oil Chemists'' Society (AOCS) that focuses on publishing high-quality peer-reviewed papers and invited reviews in the general area of lipid research, including chemistry, biochemistry, clinical nutrition, and metabolism. In addition, Lipids publishes papers establishing novel methods for addressing research questions in the field of lipid research.
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