Bioelectric; Neuromodulation; Epilepsy; DBS; High-frequency stimulation; Low frequency stimulation.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-10-08 DOI:10.1007/s10072-025-08552-6

Faeze Sadat Ahmadi Tabatabaei, Sam Zarbakhsh, Mohammad Taghi Joghataei, Samaneh Dehghan, Marzieh Khodadai, Nooshin Ahmadirad

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引用次数: 0

Abstract

Drug-resistant epilepsy affects a significant portion of epileptic patients, necessitating alternative treatment strategies beyond pharmacological interventions. Bioelectric medicine, employing techniques like vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation, has emerged as a promising approach. This review comparatively analyzes the mechanisms and clinical outcomes of high-frequency stimulation and low-frequency stimulation in the context of epilepsy treatment. We delve into the synaptic plasticity, neuronal network modulation, and neurochemical alterations induced by these stimulation paradigms, highlighting their potential to disrupt pathological synchronization and reduce seizure frequency. Furthermore, we discuss the rationale for selecting specific stimulation frequencies and target brain regions, considering the heterogeneity of epilepsy syndromes. By synthesizing existing literature, this review aims to provide a comprehensive overview of bioelectric approaches in epilepsy, informing future research and clinical applications.

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生物;神经调节;癫痫;星展银行;高频刺激;低频刺激。

耐药癫痫影响了很大一部分癫痫患者，需要药物干预之外的替代治疗策略。采用迷走神经刺激、深部脑刺激和反应性神经刺激等技术的生物电医学已经成为一种很有前途的方法。本文就高频刺激和低频刺激在癫痫治疗中的作用机制和临床效果进行比较分析。我们深入研究了这些刺激模式引起的突触可塑性、神经元网络调节和神经化学改变，强调了它们破坏病理同步和减少癫痫发作频率的潜力。此外，考虑到癫痫综合征的异质性，我们讨论了选择特定刺激频率和靶脑区的基本原理。通过对现有文献的综合，本文旨在对生物电治疗癫痫的方法进行综述，为今后的研究和临床应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.