Innovations in Heart Transplantation: Partial Heart Transplantation and Xenotransplantation.

IF 1.6 Q2 SURGERY

Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery Pub Date : 2025-10-07 DOI:10.1177/15569845251375442

Zachary T Silvano, Vincent S Alexander, Sreeja Choppara, Andrew D Vogel, Herra Javed, John Treffalls, T Konrad Rajab

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引用次数: 0

Abstract

Despite efforts to improve donor heart allocation policies, geographic disparities, logistical challenges and patient criteria limit organ availability. However, recent surgical innovations offer potential solutions. These include partial heart transplantation and xenotransplantation. Partial heart transplantation is a new procedure with the potential to address several clinical challenges in treating congenital heart defects. Cardiac xenotransplantation involves the transplantation of genetically modified porcine hearts into humans, offering a potential solution to the shortage of donor organs. Although immunologic barriers and ethical concerns remain, ongoing research aims to mitigate the risks and optimize outcomes, providing hope for patients in need. These innovative surgical approaches offer promising avenues for addressing the critical shortage of donor hearts and with ongoing research, may hold the potential to revolutionize heart transplantation, and improve outcomes for patients facing terminal heart failure.

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心脏移植的创新：部分心脏移植和异种移植。

尽管努力改善供体心脏分配政策，但地域差异、后勤挑战和患者标准限制了器官的可用性。然而，最近的外科创新提供了潜在的解决方案。这包括部分心脏移植和异种心脏移植。部分心脏移植是一项新的手术，有可能解决治疗先天性心脏缺陷的几个临床挑战。心脏异种移植涉及将转基因猪心脏移植到人类身上，为供体器官短缺提供了一个潜在的解决方案。尽管免疫障碍和伦理问题仍然存在，但正在进行的研究旨在减轻风险并优化结果，为有需要的患者提供希望。这些创新的手术方法为解决供体心脏的严重短缺提供了有希望的途径，并且正在进行的研究可能具有彻底改变心脏移植的潜力，并改善终末期心力衰竭患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery SURGERY-

CiteScore

2.00

自引率

6.70%

发文量

期刊介绍： Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery is the first journal whose main mission is to disseminate information specifically about advances in technology and techniques that lead to less invasive treatment of cardiothoracic and vascular disease. It delivers cutting edge original research, reviews, essays, case reports, and editorials from the pioneers and experts in the field of minimally invasive cardiothoracic and vascular disease, including biomedical engineers. Also included are papers presented at the annual ISMICS meeting. Official Journal of the International Society for Minimally Invasive Cardiothoracic Surgery