Glycemic Variability and Frailty Risk in Intensive Care: A Retrospective Cohort Study of 18 650 Older People.

IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY
Xinya Li, Lei Wang, Xin Liang, Yitong Ling, Yonglan Tang, Jinmiao Meng, Hongtao Cheng, Jun Lyu, Yu Wang
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引用次数: 0

Abstract

Background: Frailty, a syndrome marked by multisystem decline, is linked to worse outcomes in ICU patients. While glycemic variability (GV) has been associated with prognosis in various diseases, its relationship with frailty risk in ICU patients remains unclear.

Methods: This study included 18 650 older patients admitted to the ICU for the first time. GV was quantified using the coefficient of variation (CV) of blood glucose, while frailty was assessed using the Hospital Frailty Risk Score, which classified patients into non-frail and frail groups. The relationship between GV and hospital frailty risk was investigated through the use of multivariate logistic regression models, with supplementary subgroup and sensitivity analyses conducted to ensure the robustness of the findings.

Results: The overall prevalence of hospital frailty risk was 58.4%. Patients in the higher GV group (Log CV ≥ 2.96) exhibited a significantly elevated risk of hospital frailty in comparison to those in the lower GV group (Log CV < 2.96) (adjusted odds ratio = 1.39, 95% confidence interval: 1.31-1.47, p < 0.001). However, further analysis revealed that there was no non-linear relationship between GV and the risk of hospital frailty. Furthermore, the results of the sensitivity and subgroup analyses were in alignment with those of the primary analysis.

Conclusion: The study finds a significant link between elevated GV and increased hospital frailty risk in ICU patients, suggesting that GV may be an independent predictor of hospital frailty risk. Incorporating GV monitoring into routine care could help clinicians improve outcomes and optimize resource allocation for critically ill patients.

重症监护中的血糖变异性和衰弱风险:18650名老年人的回顾性队列研究
背景:虚弱是一种以多系统衰退为特征的综合征,与ICU患者的预后较差有关。虽然血糖变异性(GV)与多种疾病的预后相关,但其与ICU患者虚弱风险的关系尚不清楚。方法:本研究纳入18650例首次入住ICU的老年患者。使用血糖变异系数(CV)量化GV,而使用医院虚弱风险评分评估虚弱程度,将患者分为非虚弱组和虚弱组。通过使用多变量logistic回归模型调查GV与医院虚弱风险之间的关系,并进行补充亚组和敏感性分析,以确保研究结果的稳健性。结果:住院虚弱风险总体患病率为58.4%。与低GV组相比,高GV组患者(Log CV≥2.96)的住院虚弱风险显著升高(Log CV结论:研究发现GV升高与ICU患者住院虚弱风险增加之间存在显著联系,提示GV可能是住院虚弱风险的独立预测因子。将GV监测纳入常规护理可以帮助临床医生改善重症患者的预后并优化资源分配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.50
自引率
6.10%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.
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