Canonical correlation analysis on the association between pulmonary function and obesity in early-onset COPD: CT-based body composition analysis.

IF 3.1 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Frontiers in Medicine Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1633451

Jiaru Shi, Tianye Li, Zhenghao Chen, Luoman Su, Qiongyan Wu, Hongjun Zhao, Chengshui Chen

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引用次数: 0

Abstract

Background: While body composition impacts pulmonary function, the differential effects of visceral (VAT) vs. subcutaneous adipose tissue (SAT) in early-onset COPD remain unquantified.

Objective: To elucidate the relationship between obesity patterns and pulmonary function in early-onset COPD versus non-COPD populations, focusing on body mass index (BMI), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) distribution.

Methods: This retrospective cohort study analyzed 290 patients (144 early-onset COPD, 146 non-COPD) aged 20-50 years. Body composition (BMI, SAT, VAT) was quantified via CT at the L1 vertebral level. Pulmonary function was assessed by bronchodilator responsiveness testing (FEV₁/FVC, MEF₇₅, MEF₅₀, MEF₂₅). Canonical correlation analysis (CCA) was used to evaluate the multidimensional associations between body composition and pulmonary function.

Results: Canonical correlation analysis revealed distinct multidimensional relationships between body composition and pulmonary function across study cohorts (p < 0.05). In the early-onset COPD cohort (N = 144), a statistically significant canonical variate (r = 0.383, λ = 0.172) demonstrated moderate association strength linking body composition (X₁: BMI, SAT, VAT) with pulmonary function (Y₁: FEV₁, FVC, MEF₇₅, MEF₂₅). Conversely, the non-COPD group (N = 146) exhibited stronger canonical correlation (r = 0.537, λ = 0.405), with body composition (X₂: BMI, VAT) associating with pulmonary function (Y₂: FEV₁, FVC).

Conclusion: In summary, early-onset COPD patients with elevated BMI and VAT but reduced SAT exhibited improved pulmonary function across most parameters. This enhancement was not observed in MEF₅₀ and MEF₂₅. In contrast, the non-COPD cohort exhibits overall respiratory enhancement, as the cross-loading coefficient of MEF25-an indicator reflecting the weight of a variable in contributing to the canonical variate-is extremely small (0.05) and has a negligible impact on the overall association.

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早发性COPD患者肺功能与肥胖相关性的典型相关分析：基于ct的体成分分析

背景：虽然身体成分影响肺功能，但内脏（VAT）和皮下脂肪组织（SAT）在早发性COPD中的差异作用仍未量化。目的：通过体重指数（BMI）、内脏脂肪组织（VAT）和皮下脂肪组织（SAT）分布，探讨早发性COPD与非COPD人群中肥胖模式与肺功能的关系。方法：本回顾性队列研究分析了290例患者（144例早发性COPD， 146例非COPD），年龄20-50 岁。身体组成（BMI， SAT， VAT）通过L1椎体水平的CT量化。肺功能通过支气管扩张剂反应性测试（FEV₁/FVC, MEF₇₅，MEF₅₀，MEF₂₅）进行评估。典型相关分析（CCA）用于评估身体成分与肺功能之间的多维关联。结果：典型相关分析显示，身体成分（X1: BMI、SAT、VAT）与肺功能（Y1: FEV1、FVC、MEF75、MEF25）之间存在明显的多维关系（p λ = 0.172）。相反，非copd组（N = 146）表现出更强的典型相关性（r = 0.537,λ = 0.405），身体成分（X2: BMI， VAT）与肺功能（Y2: FEV1， FVC）相关。结论：总之，BMI和VAT升高但SAT降低的早发性COPD患者在大多数参数中表现出肺功能的改善。在MEF50和MEF25中没有观察到这种增强。相比之下，非copd队列表现出整体呼吸增强，因为mef25的交叉负荷系数（反映一个变量对典型变量的贡献权重的指标）非常小（0.05），对整体关联的影响可以忽略不计。

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来源期刊

Frontiers in Medicine Medicine-General Medicine

CiteScore

5.10

自引率

5.10%

发文量

3710

审稿时长

12 weeks

期刊介绍： Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world