A meta-analysis of the effects of long-term oxygen therapy combined with exercise rehabilitation on exercise capacity, cardiopulmonary function, and quality of life in patients with COPD.
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Abstract
Objective: To assess the effectiveness of long-term oxygen therapy (LTOT) combined with exercise rehabilitation vs. exercise rehabilitation alone in improving exercise capacity, cardiopulmonary function, and quality of life in chronic obstructive pulmonary disease (COPD) patients.
Methods: A comprehensive literature search was conducted in the Chinese Biomedical Literature Database (CBM), Wanfang, China National Knowledge Infrastructure (CNKI), Cochrane Library, EMBASE, ScienceDirect, and PubMed for studies published from January 2010 to the present. Controlled clinical trials comparing oxygen therapy and/or exercise rehabilitation in COPD patients were included. Two independent reviewers extracted data and assessed risk of bias using the Cochrane Handbook (version 5.3). Meta-analysis was performed using RevMan 5.3.
Results: Nine studies (N = 703) met inclusion criteria. Compared with the control group (CG), the combined LTOT and exercise group showed significant improvements in 6-min walk distance (6MWD), forced expiratory volume in 1 s (FEV1), and FEV1/FVC ratio (P < 0.05). PaO2 levels tended to be higher but showed substantial heterogeneity. No significant differences were observed in blood oxygen saturation, heart rate, or PaCO2. Quality of life significantly improved in the combined therapy group.
Conclusion: LTOT combined with exercise rehabilitation is more effective than exercise alone in improving exercise capacity, pulmonary function, and quality of life in COPD patients. However, cardiac benefits remain unclear, warranting further studies.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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