Precision Photothermal Therapy at Mild Temperature: NIR-II Imaging-Guided, H2O2-Responsive Stealth Nanobomb (Adv. Healthcare Mater. 26/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-10-08 DOI:10.1002/adhm.70239

Gongcheng Ma, Qihang Ding, Yue Wang, Zhiwei Zhang, Yuding Zhang, Hui Shi, Lintao Cai, Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim

引用次数: 0

Abstract

Precision Photothermal Therapy

This work introduces a novel Stealth NanoBomb (SNB) for precision photothermal therapy at mild temperatures (<45°C), designed to enhance cancer treatment efficacy. The SNB, composed of small-molecule NIR-II AIEgens and CO carrier polymers, selectively releases CO in response to H₂O₂ in the tumor microenvironment, effectively inhibiting heat shock proteins and improving therapeutic outcomes. More details can be found in the Research Article by Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim, and co-workers (DOI: 10.1002/adhm.202402767).

Abstract Image

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在温和温度下的精确光热治疗：NIR-II成像引导，h2o2响应隐身纳米炸弹（Adv. Healthcare Mater. 26/2025）

精密光热治疗本工作介绍了一种新型的隐身纳米炸弹（SNB），用于在温和温度（<45°C）下进行精密光热治疗，旨在提高癌症治疗效果。SNB由小分子NIR-II AIEgens和CO载体聚合物组成，在肿瘤微环境中选择性释放CO以响应H2O2，有效抑制热休克蛋白，改善治疗效果。更多细节可以在龚平、张鹏飞、郑震、金钟升及其同事的研究文章中找到（DOI: 10.1002/ admm .202402767）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.