Non-covalently Functionalized Carbon Nanotube by Hyaluronic Acid Based Azo Polymer for Photothermal Elimination of Tumor Cells

IF 4 2区化学 Q2 POLYMER SCIENCE

Chinese Journal of Polymer Science Pub Date : 2025-08-01 DOI:10.1007/s10118-025-3393-8

He-Ting Li, Wen-Long Zhang, Ya-Ning He

{"title":"Non-covalently Functionalized Carbon Nanotube by Hyaluronic Acid Based Azo Polymer for Photothermal Elimination of Tumor Cells","authors":"He-Ting Li, Wen-Long Zhang, Ya-Ning He","doi":"10.1007/s10118-025-3393-8","DOIUrl":null,"url":null,"abstract":"<div><p>Photothermal therapy has been renowned for its non-invasive and highly precise approach in cancer treatment. Therefore, the synthesis of suitable photothermal agent has attracted wide attention. In this study, a non-covalent method for modifying carbon nanotube by hyaluronic acid based azo polymer was proposed. Hyaluronic acid based azo polymer was attached to the surface of carbon nanotube <i>via</i> the <i>π</i>-<i>π</i> interaction and hydrophobic interaction between azo moiety and the wall of carbon nanotube. After the self-assembly process, the modification was demonstrated with transmission electron microscopy, infrared spectra and thermal gravimetric analysis. The modified carbon nanotube (HA-MWCNT) was endowed with both the tumor cell targeting property of hyaluronic acid and the excellent photothermal effect of carbon nanotube, enabling it to serve as photothermal agent for eliminating tumor cells. Upon co-culture with HeLa cells, HA-MWCNT was proved to exhibit low cytotoxicity without irradiation. After being irradiated with infrared laser light, the HeLa cells cultured with HA-MWCNT perished due to the heat generated by the endocytosed HA-MWCNT, which attested to the potential of HA-MWCNT as a photothermal agent for cancer treatment.</p></div>","PeriodicalId":517,"journal":{"name":"Chinese Journal of Polymer Science","volume":"43 10","pages":"1785 - 1791"},"PeriodicalIF":4.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10118-025-3393-8","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

Photothermal therapy has been renowned for its non-invasive and highly precise approach in cancer treatment. Therefore, the synthesis of suitable photothermal agent has attracted wide attention. In this study, a non-covalent method for modifying carbon nanotube by hyaluronic acid based azo polymer was proposed. Hyaluronic acid based azo polymer was attached to the surface of carbon nanotube via the π-π interaction and hydrophobic interaction between azo moiety and the wall of carbon nanotube. After the self-assembly process, the modification was demonstrated with transmission electron microscopy, infrared spectra and thermal gravimetric analysis. The modified carbon nanotube (HA-MWCNT) was endowed with both the tumor cell targeting property of hyaluronic acid and the excellent photothermal effect of carbon nanotube, enabling it to serve as photothermal agent for eliminating tumor cells. Upon co-culture with HeLa cells, HA-MWCNT was proved to exhibit low cytotoxicity without irradiation. After being irradiated with infrared laser light, the HeLa cells cultured with HA-MWCNT perished due to the heat generated by the endocytosed HA-MWCNT, which attested to the potential of HA-MWCNT as a photothermal agent for cancer treatment.

查看原文本刊更多论文

透明质酸基偶氮聚合物非共价功能化碳纳米管光热消除肿瘤细胞

光热疗法在癌症治疗中以其非侵入性和高度精确的方法而闻名。因此，合成合适的光热剂引起了广泛的关注。本研究提出了一种以透明质酸为基础的偶氮聚合物修饰碳纳米管的非共价方法。透明质酸基偶氮聚合物通过偶氮基团与碳纳米管壁之间的π-π相互作用和疏水相互作用附着在碳纳米管表面。自组装完成后，通过透射电镜、红外光谱和热重分析对改性进行了验证。改性碳纳米管（HA-MWCNT）具有透明质酸靶向肿瘤细胞的特性和碳纳米管优良的光热效应，可以作为光热剂杀灭肿瘤细胞。在与HeLa细胞共培养后，证实HA-MWCNT在没有辐照的情况下表现出低细胞毒性。经红外激光照射后，HA-MWCNT培养的HeLa细胞由于内吞HA-MWCNT产生的热量而死亡，这证明了HA-MWCNT作为光热剂治疗癌症的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chinese Journal of Polymer Science 化学-高分子科学

CiteScore

7.10

自引率

11.60%

发文量

218

审稿时长

6.0 months

期刊介绍： Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985. CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.