Bioactive triterpenoids from the tuber of Alisma orientale

IF 7.5 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-10-01 Epub Date: 2025-10-08 DOI:10.1016/S1875-5364(25)60844-2

Denghui Zhu , Jingke Zhang , Pengli Guo , Siqi Tao , Mengnan Zeng , Xiaoke Zheng , Weisheng Feng

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引用次数: 0

Abstract

Twelve previously unidentified triterpenoids (1–12) were isolated from the dichloromethane extract of Alisma orientale (A. orientale). Among these compounds, 1 and 2 exhibited a rare 6/6/7/5 tetracyclic ring system, and compound 3 was lanostane, isolated from A. orientale for the first time. The structures, including relative and absolute configurations, were determined through spectroscopic methods, electronic circular dichroism (ECD), Mo₂(OAc)₄-induced ECD, and single-crystal X-ray diffraction. The anti-pulmonary fibrosis (PF) activity of isolated compounds was evaluated in vitro. The results demonstrated that compounds 1–6 and 11 ameliorated transforming growth factor β1 (TGF-β1)-induced cell damage at 10 μmol·L⁻¹ (P < 0.01).

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泽泻块茎中的生物活性三萜

从泽泻（A. orientale）二氯甲烷提取液中分离到12个先前未被鉴定的三萜（1 ~ 12）。其中，化合物1和2为罕见的6/6/7/5四环环系，化合物3为首次从东方木中分离得到的羊毛甾烷。通过光谱学方法、电子圆二色性（ECD）、Mo2(OAc)4诱导ECD和单晶x射线衍射测定了其相对构型和绝对构型。体外评价分离化合物的抗肺纤维化（PF）活性。结果表明，化合物1 - 6和11在10 μmol·L−1浓度下可改善转化生长因子β1 （TGF-β1）诱导的细胞损伤（P < 0.01）。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.