High-speed photoacoustic and ultrasonic computed tomography of the breast tumor for early diagnosis with enhanced accuracy

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-10-08 DOI:10.1126/sciadv.adz2046

Keer Huang, Peifen Fu, Hengyue Zhu, Jingyi Feng, Liang Zhang, Baohua Wang, Yuexin Lu, Di Zhang, Minya Yao, Luyan Chen, Yue Ying, Jiali Chen, Xiaolong Li, Yang Wu, Wei Xiong, Jun Li, Yaping Wu, Jing Sun, Hong Zhang, Li Lin

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Abstract

We have developed a high-speed dual-modal imaging system (HDMI), designed to concurrently reveal anatomical and hematogenous details of the human breast within seconds. Through innovative system design and technical advancements, HDMI integrates large-view photoacoustic and ultrasonic computed tomography with standardized scanning and batch data processing for computer-aided diagnosis. It achieves dual-modal imaging at a 10-hertz frame rate and completes a whole-breast scan in 12 seconds, providing penetration up to 5 centimeters in vivo. In a clinical study involving 170 patients with 186 breast tumors, we developed a diagnostic model leveraging combined photoacoustic and ultrasound features. In a triple-blinded comparison using pathological diagnosis as the ground truth, HDMI significantly improved diagnostic specificity from 22.5 to 75.0% compared to clinical ultrasonography. This technology shows strong potential for early breast tumor diagnosis, offering enhanced accuracy without the need for ionizing radiation, exogenous contrast agents, pain, invasiveness, operator dependence, or extended examination times.

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高速光声和超声计算机断层扫描乳腺肿瘤的早期诊断，提高准确性

我们开发了一种高速双模成像系统（HDMI），旨在在几秒钟内同时显示人体乳房的解剖和血液细节。通过创新的系统设计和技术进步，HDMI将大视场光声和超声计算机断层扫描与标准化扫描和批量数据处理相结合，用于计算机辅助诊断。它以10赫兹的帧率实现双峰成像，并在12秒内完成整个乳房扫描，在体内提供高达5厘米的穿透。在一项涉及170例乳腺肿瘤患者186例的临床研究中，我们开发了一种结合光声和超声特征的诊断模型。在以病理诊断为基础的三盲比较中，与临床超声检查相比，HDMI显著提高了诊断特异性，从22.5%提高到75.0%。这项技术在早期乳腺肿瘤诊断中显示出强大的潜力，提供了更高的准确性，而不需要电离辐射、外源性造影剂、疼痛、侵入性、操作员依赖性或延长检查时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.