Mouse olfactory system acts as anemo-detector and anemo-discriminator

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-10-08 DOI:10.1126/sciadv.adq8390

Sarang Mahajan, Susobhan Das, Suhel Tamboli, Sanyukta Pandey, Anindya S. Bhattacharjee, Meenakshi Pardasani, Priyadharshini Srikanth, Shruti D. Marathe, Avi Adlakha, Lavanya Ranjan, Nixon M. Abraham

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Abstract

Airflow detection while smelling is a fundamental requirement for olfaction, yet the mechanisms underlying such multimodal processing in the olfactory system remain unknown. We report here that mice can accurately discriminate airflow in the absence of whiskers. Modulated sniffing and refined calcium signaling in the olfactory bulb inhibitory network during olfactory anemo-discriminations confirmed the orthonasal airflow information processing. Genetic perturbation of AMPAR function and optogenetic control bidirectionally shifted the anemo-discrimination learning pace, with contrasting phenotypes observed for odor learning, engagement of inhibitory circuits, and setting the optimal inhibition level for stimulus refinement. Enhanced learning caused by multimodal odor-airflow stimuli at subthreshold levels confirmed the heightened olfactory perception by mechanical stimuli. Our results thus explain the multimodality of olfaction and reveal the unexplored dimensionality of odor perception.

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小鼠的嗅觉系统具有感知和辨别风的作用

嗅觉时的气流检测是嗅觉的基本要求，但嗅觉系统中这种多模态处理的机制尚不清楚。我们在这里报告，小鼠可以准确地辨别气流在没有胡须。嗅觉气流辨别过程中嗅球抑制网络中嗅探和精细钙信号的调节证实了正交鼻气流信息处理。AMPAR功能的遗传扰动和光遗传控制双向改变了嗅觉辨别学习的速度，在气味学习、抑制回路的参与以及设置刺激细化的最佳抑制水平方面观察到不同的表型。多模态气味-气流刺激在阈下水平引起的学习增强证实了机械刺激引起的嗅觉感知增强。因此，我们的研究结果解释了嗅觉的多模态，并揭示了气味感知的未探索维度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.