Mitochondrial sodium-calcium exchange—Can TMEM65 do it alone?

IF 30.9 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-10-07 DOI:10.1016/j.cmet.2025.09.005

Joanne F. Garbincius, John W. Elrod

引用次数: 0

Abstract

The mechanisms mediating calcium transport into and out of the mitochondrial matrix have critical implications for signaling, bioenergetics, and cell death. Zhang et al.¹ propose that the protein TMEM65, recently identified as a key component of the mitochondrial calcium efflux machinery, functions as the mitochondrial sodium/calcium exchanger. Their report encourages critical re-examination of the components required for mitochondrial calcium handling.

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线粒体钠钙交换——TMEM65能单独完成吗？

钙转运进出线粒体基质的机制对信号传导、生物能量学和细胞死亡具有重要意义。Zhang等人1提出，最近发现的线粒体钙外排机制的关键组成部分TMEM65蛋白起着线粒体钠/钙交换器的作用。他们的报告鼓励对线粒体钙处理所需的成分进行批判性的重新检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.