Subjective cognitive decline in individuals with isolated REM sleep behavior disorder.

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-10-07 DOI:10.1038/s41531-025-01161-2

Anja Ophey,Sinah Röttgen,Christopher E J Doppler,Daniel Scharfenberg,Konstantin Kufer,Ezequiel Farrher,Gereon R Fink,Michael Sommerauer,Elke Kalbe

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引用次数: 0

Abstract

Subjective cognitive decline (SCD) may constitute an early marker of mild cognitive impairment (MCI) in individuals with isolated REM sleep behavior disorder (iRBD). In this cross-sectional study, 80 individuals with iRBD were classified into iRBD with MCI (RBD.MCI), with SCD (RBD.SCD+), and without both (RBD.SCD-) based on neuropsychological testing and the Multi-SubCoDE questionnaire. The prevalence of SCD in iRBD was 36.3%, with predominance of the amnestic multi-domain SCD profile. RBD.SCD+ reported more severe depressive symptoms than RBD.SCD- and showed lower cognitive performance than RBD.SCD- in global cognition and attention & working memory. Magnetic resonance imaging analyses revealed lower grey matter volume in the left superior frontal gyrus for RBD.SCD+ than RBD.SCD-, which was associated with increased SCD-severity and lower global cognition. SCD without MCI in iRBD is associated with subtle cognitive deficits and structural brain changes. The prognostic value of SCD in iRBD should be further determined in longitudinal studies.

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孤立的快速眼动睡眠行为障碍患者的主观认知能力下降。

主观认知能力下降（SCD）可能是孤立性快速眼动睡眠行为障碍（iRBD）患者轻度认知障碍（MCI）的早期标志。在这项横断面研究中，80名iRBD患者被归类为iRBD合并MCI （RBD）。MCI), SCD （RBD）。基于神经心理测试和Multi-SubCoDE问卷，SCD+)和两者均无（RBD.SCD-）。iRBD中SCD的患病率为36.3%，以遗忘型多域SCD为主。RBD。SCD+报告的抑郁症状比RBD更严重。并且表现出比RBD更低的认知能力。SCD-在全局认知、注意和工作记忆中的作用。磁共振成像分析显示RBD患者左侧额上回灰质体积较低。SCD+优于RBD。SCD-，这与SCD严重程度增加和整体认知能力下降有关。iRBD中无MCI的SCD与微妙的认知缺陷和大脑结构改变有关。SCD在iRBD中的预后价值应在纵向研究中进一步确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.