{"title":"Comparative Evaluation of Bone Regeneration in Third Molar Extraction Using Simvastatin Powder And Simvastatin Gel-A Split-Mouth Study.","authors":"Sanika Tidke, Pushkar P Waknis, Ravidra Badhe, Kalyani Bhate, Sneha Setiya, Samkit Sakhariya","doi":"10.1007/s12663-025-02497-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To evaluate and compare bone regeneration in third molar extraction using simvastatin powder and simvastatin gel.</p><p><strong>Materials and methods: </strong>A randomized, split-mouth, single-blinded, single-center trial was performed in 10 patients requiring surgical extraction of bilaterally impacted mandibular third molars. Each participant was randomly assigned to receive Gelfoam soaked with drug simvastatin (10 mg) in one socket and simvastatin gel in other socket. RVG was taken after the first, fourth, eighth, and twelfth weeks after analyzing the gray mean scale value with a histogram to determine bone regeneration. On Day 1 and Day 7, pain and wound healing were measured using the VAS scale and the Landry et al. scale, respectively.</p><p><strong>Result: </strong>The paired t test was used to compare the two groups; individual means for both groups revealed a significant result, with the greatest mean appearing at the 12th week, suggesting that simvastatin usage aids bone regeneration.</p><p><strong>Conclusion: </strong>We recommend using simvastatin after every third molar operation since it aids in bone regeneration. Even though simvastatin gel is cost effective, it must be prepared fresh before use. Sustained release of simvastatin should be further investigated using different carrier methods that would prove to be beneficial.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 5","pages":"1458-1467"},"PeriodicalIF":0.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496384/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Maxillofacial & Oral Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12663-025-02497-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/13 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To evaluate and compare bone regeneration in third molar extraction using simvastatin powder and simvastatin gel.
Materials and methods: A randomized, split-mouth, single-blinded, single-center trial was performed in 10 patients requiring surgical extraction of bilaterally impacted mandibular third molars. Each participant was randomly assigned to receive Gelfoam soaked with drug simvastatin (10 mg) in one socket and simvastatin gel in other socket. RVG was taken after the first, fourth, eighth, and twelfth weeks after analyzing the gray mean scale value with a histogram to determine bone regeneration. On Day 1 and Day 7, pain and wound healing were measured using the VAS scale and the Landry et al. scale, respectively.
Result: The paired t test was used to compare the two groups; individual means for both groups revealed a significant result, with the greatest mean appearing at the 12th week, suggesting that simvastatin usage aids bone regeneration.
Conclusion: We recommend using simvastatin after every third molar operation since it aids in bone regeneration. Even though simvastatin gel is cost effective, it must be prepared fresh before use. Sustained release of simvastatin should be further investigated using different carrier methods that would prove to be beneficial.
期刊介绍:
This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.