Association of the high-density lipoprotein cholesterol to C-reactive protein ratio with pulmonary function among U.S. adults: A cross-sectional study from NHANES 2007–2010

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-10-04 DOI:10.1016/j.rmed.2025.108397

Xue-Feng Li , Mei-Ling Zhang

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引用次数: 0

Abstract

Background

Previous studies have shown a strong association between impaired pulmonary function and both lipid metabolic disorders and inflammatory states. However, the relationship between the high-density lipoprotein cholesterol (HDL-C) to C-reactive protein (CRP) ratio and pulmonary function remains unclear. The aim of this study was to investigate the relationship between HDL-C/CRP and pulmonary function, including forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1).

Methods

This cross-sectional study included 5185 participants from the National Health and Nutrition Examination Survey (NHANES, 2007–2010). The association between the HDL-C/CRP ratio and pulmonary function parameters (FVC, FEV1, and the FEV1/FVC ratio) was assessed using multivariable linear regression models adjusted for potential confounders. Nonlinear associations were explored with smoothed curve fitting. Subgroup and sensitivity analyses were performed to evaluate the robustness of the associations.

Results

Our study showed that the natural logarithm of the HDL-C/CRP ratio, Ln(HDL-C/CRP), both as a continuous variable and as a categorical variable (tertiles), was linearly and positively correlated with pulmonary function parameters (FVC and FEV1). However, no statistically significant correlation was shown between FEV1/FVC and Ln(HDL-C/CRP). Subsequent subgroup and sensitivity analyses further confirmed the significant associations between lung function parameters (FEV1 and FVC) and the Ln(HDL-C/CRP), and validated the robustness and reliability of the results.

Conclusions

This cross-sectional study found that elevated HDL-C/CRP ratios are positively related to pulmonary function parameters (FVC and FEV1) among U.S. adults. Additionally, this suggested that HDL-C/CRP ratio may serve as an indicator for assessing improvements in these parameters.

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美国成人高密度脂蛋白胆固醇与c反应蛋白比值与肺功能的关系：来自NHANES 2007-2010的横断面研究

背景：先前的研究表明，肺功能受损与脂质代谢紊乱和炎症状态之间存在很强的相关性。然而，高密度脂蛋白胆固醇（HDL-C）与c反应蛋白（CRP）比值与肺功能之间的关系尚不清楚。本研究的目的是探讨HDL-C/CRP与肺功能的关系，包括用力肺活量（FVC）和用力呼气量（FEV1）。方法：本横断面研究包括5185名来自国家健康和营养检查调查（NHANES, 2007-2010）的参与者。使用校正潜在混杂因素的多变量线性回归模型评估HDL-C/CRP比值与肺功能参数（FVC、FEV1和FEV1/FVC比值）之间的关系。利用光滑曲线拟合探讨非线性关联。进行亚组分析和敏感性分析来评估这些关联的稳健性。结果：我们的研究表明HDL-C/CRP比值的自然对数Ln(HDL-C/CRP)，无论是作为连续变量还是作为分类变量（tertiles），都与肺功能参数（FVC和FEV1）呈线性正相关。然而，FEV1/FVC与Ln（HDL-C/CRP）之间无统计学意义的相关性。随后的亚组分析和敏感性分析进一步证实了肺功能参数（FEV1和FVC）与Ln（HDL-C/CRP）之间的显著相关性，验证了结果的稳健性和可靠性。结论：这项横断面研究发现，在美国成年人中，HDL-C/CRP比值升高与肺功能参数（FVC和FEV1）呈正相关。此外，这表明HDL-C/CRP比率可以作为评估这些参数改善的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.