Effects of Aging on Mammalian Spermatogenesis From a Cellular Perspective

IF 3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2025-10-07 DOI:10.1002/mrd.70061

Tao Li, Wenchao Xu, Lisha Yin, Jin Zhang, Opeyemi DhikhirullahI, Zhibing Zhang, Shuiqiao Yuan

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Abstract

Aging refers to the irreversible changes in the structure and function of organisms over time. Under the influence of social and economic factors, the apparent effect of aging on female fertility has been widely recognized; however, its effect on male fertility has not received sufficient attention. Spermatogenic stem cells can differentiate and produce gametes continuously for a long time in a man's life, but more significant cumulative effects often occur over time. These age-related effects mainly manifest as increased chromosomal abnormalities and DNA damage, lower levels of sex hormones, impaired testicular function, and reduced spermatozoa count and quality. In the past, more attention has been paid to some of the macroscopic changes associated with aging. In this review, we will focus on the cellular level, discussing the effects of aging on male germ cells and the changes in the spermatogenic microenvironment, which consists mainly of Sertoli and Leydig cells.

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从细胞角度看衰老对哺乳动物精子发生的影响。

衰老是指生物体的结构和功能随着时间的推移而发生的不可逆转的变化。在社会经济因素的影响下，老龄化对女性生育能力的明显影响已得到广泛认可；然而，它对男性生育能力的影响还没有得到足够的重视。生精干细胞可以在一个人的一生中持续很长时间地分化和产生配子，但更显著的累积效应往往会随着时间的推移而出现。这些与年龄相关的影响主要表现为染色体异常和DNA损伤增加，性激素水平降低，睾丸功能受损，精子数量和质量降低。过去，人们更多地关注与衰老相关的一些宏观变化。本文将从细胞水平上，探讨衰老对男性生殖细胞的影响及生精微环境的变化，主要包括支持细胞和间质细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.