Association between vitamin D receptor gene polymorphisms, inflammatory cytokines (IL-1, IL-6, and IL-10), and fracture healing in sports-related injuries.
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Abstract
Background: In this study, we analysed the correlation between polymorphisms in the Vitamin D receptors (VDR) gene at the Apa I and FoK I loci and sports-related fractures (SRF). We also examined the inflammatory cytokines IL-1, IL-6, and IL-10 to explore their potential role in fracture healing.
Methods: A retrospective analysis was conducted on 110 patients with SRF admitted to our hospital from February 2023 to October 2023. Among these, 41 patients with poor fracture healing (research group) and 69 patients with good fracture healing (control group) were included. Serum levels of Vitamin D (VD), bone mineral density (BMD), and inflammatory cytokines (IL-1, IL-6, and IL-10) were measured to assess their relationship with fracture healing. Additionally, polymorphisms in the VDR gene at the Apa I and FoK I loci were analysed to determine the differences between the two groups.
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The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
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