Prognostic value of CRP, PCT, and TNF-a, D-lactate, DAO, and endotoxin on survival of patients with severe craniocerebral injury.

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-09-05 DOI:10.5937/jomb0-54673

Ming Gong, Han Peng

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引用次数: 0

Abstract

Background: Hyperbaric oxygen therapy is an important treatment method for early consciousness recovery and rehabilitation after brain trauma. In this study, we investigated the effects of hyperbaric oxygen combined with probiotics nutritional supplements (PNS) on patients with severe craniocerebral injury complicated with swallowing disorders in the Intensive care unit.

Methods: Seventy-four patients with severe craniocerebral injury who received hyperbaric oxygen therapy in the ICU of our hospital from July 2020 to October 2023 were selected for retrospective analysis. Among them, 35 received conventional NS (control groups), and another 39 received PNS (research group). Inflammatory factors, T-lymphocyte subsets, and gastrointestinal mucosal function were compared between the two groups before and after treatment. In addition, patients' neurological function was assessed using the Glasgow Coma Scale (GCS), the Fugl-Meyer Assessment (FMA), and the National Institutes of Health Stroke Scale (NIHSS). Finally, the incidence of adverse effects between the two groups was counted.

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CRP、PCT、TNF-a、d -乳酸、DAO、内毒素对重型颅脑损伤患者生存的预后价值

背景：高压氧治疗是颅脑外伤后早期意识恢复和康复的重要治疗手段。在这项研究中，我们研究了高压氧联合益生菌营养补充剂（PNS）对重症监护病房重症颅脑损伤合并吞咽障碍患者的影响。方法：选取2020年7月至2023年10月在我院ICU接受高压氧治疗的重型颅脑损伤患者74例进行回顾性分析。其中常规NS 35例（对照组），PNS 39例（研究组）。比较两组患者治疗前后的炎症因子、t淋巴细胞亚群及胃肠道黏膜功能。此外，采用格拉斯哥昏迷量表（GCS）、Fugl-Meyer评估量表（FMA）和美国国立卫生研究院卒中量表（NIHSS）对患者的神经功能进行评估。最后统计两组不良反应发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.